The neurocircuitry involved in oxytocin modulation of methamphetamine addiction

SJ Baracz, JL Cornish - Frontiers in neuroendocrinology, 2016 - Elsevier
The role of oxytocin in attenuating the abuse of licit and illicit drugs, including the
psychostimulant methamphetamine, has been examined with increased ferocity in recent …

Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in …

DS Carson, GE Hunt, AJ Guastella, L Barber… - Addiction …, 2010 - Wiley Online Library
Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in
the treatment of drug dependence and drug withdrawal. Oxytocin reduces …

Chronic methamphetamine treatment induces oxytocin receptor up-regulation in the amygdala and hypothalamus via an adenosine A2A receptor-independent …

P Zanos, SR Wright, P Georgiou, JH Yoo… - Pharmacology …, 2014 - Elsevier
There is mounting evidence that the neuropeptide oxytocin is a possible candidate for the
treatment of drug addiction. Oxytocin was shown to reduce methamphetamine self …

Targeting the oxytocin system to treat addictive disorders: rationale and progress to date

MR Lee, MCH Rohn, G Tanda, L Leggio - CNS drugs, 2016 - Springer
The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning, and
memory processes. As such, there is increasing interest in oxytocin as a potential treatment …

The role of oxytocin in alcohol and drug abuse

CE King, A Gano, HC Becker - Brain research, 2020 - Elsevier
The neuropeptide oxytocin (OXT) plays a key role in adaptive processes associated with
reward, tolerance, memory and stress responses. Through interactions with brain reward …

Oxytocin acts in nucleus accumbens to attenuate methamphetamine seeking and demand

BM Cox, BS Bentzley, H Regen-Tuero, RE See… - Biological …, 2017 - Elsevier
Background Evidence indicates that oxytocin, an endogenous peptide well known for its role
in social behaviors, childbirth, and lactation, is a promising addiction pharmacotherapy. We …

Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats

DS Carson, JL Cornish, AJ Guastella, GE Hunt… - …, 2010 - Elsevier
There is emerging evidence that the neuropeptide oxytocin may be utilised as a treatment
for various psychopathologies, including drug addictions. Here we used an animal model to …

The potential role of oxytocin in addiction: What is the target process?

F Sanna, MA De Luca - Current Opinion in Pharmacology, 2021 - Elsevier
Oxytocin regulates a variety of centrally-mediated functions, ranging from socio-sexual
behavior, maternal care, and affiliation to fear, stress, anxiety. In the past years, both clinical …

[HTML][HTML] Oxytocin, a novel treatment for methamphetamine use disorder

AN Edinoff, E Thompson, CE Merriman… - Neurology …, 2022 - mdpi.com
The treatment of substance abuse with oxytocin is a novel approach to a challenging public
health issue that continues to contribute to a growing economic cost for societies worldwide …

A brief history of oxytocin and its role in modulating psychostimulant effects

DS Carson, AJ Guastella, ER Taylor… - Journal of …, 2013 - journals.sagepub.com
Over the past century, the polypeptide oxytocin has played an important role in medicine
with major highlights including the identification of its involvement in parturition and the milk …