BACKGROUND: There have been inconsistent reports on whether opioids promote or inhibit
lung cancer growth. In this study, we suggest that opioid growth factor receptor (OGFR), a …

BACKGROUND: The possibility that μ opioid agonists can influence cancer recurrence is a
subject of recent interest. Epidemiologic studies suggested that there were differences in …

Background Morphine, a µ-opioid receptor (MOR) agonist, has been shown to be related to
the activity of cancer cells, and a higher morphine dosage reduces the survival time of …

BACKGROUND: Epidermal growth factor receptor (EGFR) is coactivated by the μ-opioid
receptor (MOR), expressed on non–small cell lung cancer (NSCLC) cells and human lung …

Background Recent epidemiologic studies suggesting that there were differences in cancer
recurrence contingent on anesthetic regimens have raised the possibility that μ-opioid …

Recent epidemiologic studies implying differences in cancer recurrence based on
anesthetic regimens raise the possibility that the mu opioid receptor (MOR) can influence …

The opioid growth factor (OGF) regulates cell proliferation of human cancer cells through the
cyclin-dependent kinase inhibitory pathway, with mediation of this action by the OGF …

Purpose Although many oral cancer patients require opioids, the effects of morphine and
related drugs on oral cancer progression have not been well established. Thus, we …

The opioid growth factor (OGF) is a constitutively expressed negative growth regulator
whose action is mediated by the OGF receptor (OGFr). The OGF-OGFr axis tonically …

Opioid growth factor (OGF) is an endogenous opioid peptide ([Met5]-enkephalin) that
interacts with the OGF receptor (OGFr). OGF serves as a constitutively expressed and …