Chlorogenic Acid Protects Against Indomethacin-Induced Inflammation and Mucosa Damage by Decreasing Bacteroides-Derived LPS

Y Yan, X Zhou, K Guo, F Zhou, H Yang - Frontiers in immunology, 2020 - frontiersin.org
Background: Chlorogenic acid (CGA), a natural bioactive polyphenol, exerts anti-
inflammatory, antioxidant, and antibacterial effects that support the maintenance of intestinal …

Chlorogenic acid alleviates colon mucosal damage induced by a high‐fat diet via gut microflora adjustment to increase short‐chain fatty acid accumulation in rats

MG Xie, YQ Fei, Y Wang, WY Wang… - Oxidative Medicine and …, 2021 - Wiley Online Library
A high‐fat diet (HFD) has been previously associated with the development of diseases
such as chronic colitis. While chlorogenic acid (CGA) is known to exhibit potent antioxidant …

Chlorogenic acid ameliorates colitis and alters colonic microbiota in a mouse model of dextran sulfate sodium-induced colitis

P Zhang, H Jiao, C Wang, Y Lin, S You - Frontiers in Physiology, 2019 - frontiersin.org
This study evaluated the mitigating effects of dietary chlorogenic acid (CGA) on colon
damage and the bacterial profile in a mouse model of dextran sulfate sodium (DSS)-induced …

Chlorogenic acid ameliorates post‐infectious irritable bowel syndrome by regulating extracellular vesicles of gut microbes

C Zheng, Y Zhong, W Zhang, Z Wang, H Xiao… - Advanced …, 2023 - Wiley Online Library
Post‐infectious irritable bowel syndrome (PI‐IBS) occurs after acute infectious diarrhea, and
dysbiosis can be involved in its pathogenesis. Here, the role of chlorogenic acid (CGA) is …

Chlorogenic Acid Ameliorates Experimental Colitis by Promoting Growth of Akkermansia in Mice

Z Zhang, X Wu, S Cao, M Cromie, Y Shen, Y Feng… - Nutrients, 2017 - mdpi.com
Chlorogenic acid (ChA)—one of the most abundant polyphenol compounds in the human
diet—exerts anti-inflammatory activities. The aim of this study was to investigate the effect of …

Chlorogenic acid-induced gut microbiota improves metabolic endotoxemia

X Ye, Y Liu, J Hu, Y Gao, Y Ma, D Wen - Frontiers in endocrinology, 2021 - frontiersin.org
Background Coffee can regulate glucose homeostasis but the underlying mechanism is
unclear. This study investigated the preventive and therapeutic effects of chlorogenic acid …

Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation

D Han, Y Wu, D Lu, J Pang, J Hu, X Zhang… - Cell death & …, 2023 - nature.com
Dietary phenolic acids alleviate intestinal inflammation through altering gut microbiota
composition and regulating macrophage activation. However, it is unclear how individual …

Gallic acid ameliorates colitis by trapping deleterious metabolite ammonia and improving gut microbiota dysbiosis

J Peng, T Liu, P Meng, Y Luo, S Zhu, Y Wang, M Ma… - Mbio, 2024 - Am Soc Microbiol
Gut microbiota dysbiosis is causally related to inflammatory bowel disease (IBD), and
increased levels of the gut metabolite ammonia have been proposed to contribute to IBD …

Alpha‐Ketoglutarate Attenuates Colitis in Mice by Increasing Lactobacillus Abundance and Regulating Stem Cell Proliferation via Wnt‐Hippo Signaling

X Si, H Jia, N Liu, J Li, L Pan, J Wang… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope Inflammatory bowel disease is an inflammatory gastrointestinal disorder associated
with intestinal barrier damage, cell proliferation disorder, and dysbiosis of the intestinal …

Chlorogenic acid combined with epigallocatechin-3-gallate mitigates D-galactose-induced gut aging in mice

R Wei, Z Su, GG Mackenzie - Food & Function, 2023 - pubs.rsc.org
Chlorogenic acid (CGA) and epigallocatechin-3-gallate (EGCG) are major polyphenolic
constituents of coffee and green tea with beneficial health properties. In this study, we …