Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

Perineuronal nets: subtle structures with large implications

H Carceller, Y Gramuntell, P Klimczak… - The …, 2023 - journals.sagepub.com
Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

Casting a wide net: role of perineuronal nets in neural plasticity

BA Sorg, S Berretta, JM Blacktop… - Journal of …, 2016 - Soc Neuroscience
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …

[HTML][HTML] The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders

TH Wen, DK Binder, IM Ethell… - Frontiers in molecular …, 2018 - frontiersin.org
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …

[HTML][HTML] A sweet talk: the molecular systems of perineuronal nets in controlling neuronal communication

HM Van't Spijker, JCF Kwok - Frontiers in integrative neuroscience, 2017 - frontiersin.org
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of
extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons …

Perineuronal nets: plasticity, protection, and therapeutic potential

AC Reichelt, DJ Hare, TJ Bussey, LM Saksida - Trends in neurosciences, 2019 - cell.com
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

[HTML][HTML] The perineuronal net and the control of CNS plasticity

D Wang, J Fawcett - Cell and tissue research, 2012 - Springer
Perineuronal nets (PNNs) are reticular structures that surround the cell body of many
neurones, and extend along their dendrites. They are considered to be a specialized …

Perineuronal nets suppress plasticity of excitatory synapses on CA2 pyramidal neurons

KE Carstens, ML Phillips, L Pozzo-Miller… - Journal of …, 2016 - Soc Neuroscience
Long-term potentiation of excitatory synapses on pyramidal neurons in the stratum radiatum
rarely occurs in hippocampal area CA2. Here, we present evidence that perineuronal nets …

Developmental pattern of perineuronal nets in the human prefrontal cortex and their deficit in schizophrenia

SA Mauney, KM Athanas, H Pantazopoulos… - Biological …, 2013 - Elsevier
Background Perineuronal nets (PNNs) are extracellular matrix structures that enwrap many
neurons in the brain. They regulate the postnatal experience-dependent maturation of brain …