An important role for the neural extracellular matrix in modulating cortical activity-dependent
synaptic plasticity has been established by a number of recent studies. However …

Perineuronal nets (PNNs) are specialized extracellular matrix aggregates surrounding
distinct neuronal populations and regulating synaptic functions and plasticity. Previous …

Drugs that target monoaminergic transmission represent a first‐line treatment for major
depression. Though a full understanding of the mechanisms that underlie antidepressant …

The extracellular matrix is known to be involved in neuronal communication and the
regulation of plastic changes, and also considered to protect neurons and synapses against …

Brain extracellular matrix (ECM) is organized in specific patterns assumed to mirror local
features of neuronal activity and synaptic plasticity. Aggrecan‐based perineuronal nets …

Many neuropsychiatric disorders show localized dysfunction in specific cortical regions. The
mechanisms underlying such region-specific vulnerabilities are unknown. Post-mortem …

Fast-spiking parvalbumin interneurons are critical for the function of mature cortical inhibitory
circuits. Most of these neurons are enwrapped by a specialized extracellular matrix (ECM) …

As chemically specialized forms of the extracellular matrix in the central nervous system,
polyanionic perineuronal nets (PNs) contain diverse constituents, including chondroitin …