How to manage intravenous vinflunine in cancer patients with renal impairment: results of a pharmacokinetic and tolerability phase I study
N Isambert, JP Delord, JM Tourani… - British Journal of …, 2014 - Wiley Online Library
Aims Vinflunine (VFL) ditartrate, a novel tubulin‐targeted inhibitor, is registered for the
treatment of patients with advanced or metastatic urothelial transitional cell carcinoma. This …
treatment of patients with advanced or metastatic urothelial transitional cell carcinoma. This …
Vinflunine potentiates the activity of cisplatin but not 5-fluorouracil in a transplantable murine adenocarcinoma model.
SD Shnyder, PA Cooper, N Gyselinck, BT Hill… - Anticancer …, 2003 - europepmc.org
Background Vinflunine is a novel Vinca alkaloid currently undergoing Phase II clinical trials,
which have previously demonstrated anti-vascular effects in a transplantable murine colon …
which have previously demonstrated anti-vascular effects in a transplantable murine colon …
Combination chemotherapy with vindesine-ifosfamide-cisplatin (VIP) in locally advanced unresectable stage III and in stage IV non-small cell lung cancer: a phase II …
J Vansteenkiste, J Vandebroek, S Marien, L Roex… - Lung cancer, 1995 - Elsevier
The efficacy and toxicity of a regimen adding ifosfamide to the more classical cisplatin-
vindesine combination was studied in patients with advanced non-small cell lung cancer …
vindesine combination was studied in patients with advanced non-small cell lung cancer …
A phase III randomized trial comparing vindesine and cisplatin with or without ifosfamide in patients with advanced non-small-cell lung cancer: long-term follow-up …
T Kodani, H Ueoka, K Kiura, M Tabata, N Takigawa… - Lung Cancer, 2002 - Elsevier
In order to evaluate the activity and toxicity of a three-drug combination of vindesine,
ifosfamide and cisplatin (VIP) for inoperable non-small-cell lung cancer (NSCLC), we …
ifosfamide and cisplatin (VIP) for inoperable non-small-cell lung cancer (NSCLC), we …
[引用][C] Vinflunine for the treatment of metastatic transitional cell carcinoma: recent evidence from clinical trials and observational studies.
C Serrate, D Pouessel, H Gauthier, C Maignan… - 2014 - cabidigitallibrary.org
The microtubule inhibitor vinflunine is currently the only cytotoxic drug approved in Europe
for the treatment of patients with metastatic transitional cell carcinoma who failed first-line …
for the treatment of patients with metastatic transitional cell carcinoma who failed first-line …
Phase II study of vinflunine in patients with metastatic renal cell carcinoma
D Goldstein, SP Ackland, DR Bell, IN Olver… - Investigational new …, 2006 - Springer
Purpose: An open-label, multicentre, non-comparative phase II trial to determine the
response rate of intravenous vinflunine as first line chemotherapy in patients with metastatic …
response rate of intravenous vinflunine as first line chemotherapy in patients with metastatic …
Phase I trial of vinflunine and pemetrexed in refractory solid tumors
HK Sanoff, J Davies, C Walko, L Buie, WK Chiu… - Investigational new …, 2011 - Springer
Background Vinflunine is a novel vinca alkaloid with promising single agent clinical activity.
Pemetrexed has at least additive activity with other vincas. A phase I trial was undertaken to …
Pemetrexed has at least additive activity with other vincas. A phase I trial was undertaken to …
A phase I clinical and pharmacokinetic study evaluating vinflunine in combination with epirubicin as first-line treatment in metastatic breast cancer
S Chan, M Campone, A Santoro, PF Conte… - Cancer chemotherapy …, 2014 - Springer
Background Vinflunine (VFL) is a bifluorinated tubulin-targeted agent of the vinca alkaloids
class active in advanced stage breast cancer. We conducted a phase I study combining VFL …
class active in advanced stage breast cancer. We conducted a phase I study combining VFL …
Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid
A Kruczynski, F Colpaert, JP Tarayre… - Cancer chemotherapy …, 1998 - Springer
Abstract Vinflunine, or 20′, 20′-difluoro-3′, 4′-dihydrovino‐relbine, is a novel Vinca
alkaloid obtained by hemisynthesis using superacidic chemistry. The most impressive …
alkaloid obtained by hemisynthesis using superacidic chemistry. The most impressive …
Prognostic score for second-line chemotherapy of advanced non-small-cell lung cancer: external validation in a phase III trial comparing vinflunine with docetaxel
M Di Maio, M Krzakowski, R Fougeray, DM Kowalski… - Lung cancer, 2012 - Elsevier
A prognostic index for second-line chemotherapy of NSCLC was previously developed,
based on individual patient data (IPD) of nine randomized trials. In order to validate the …
based on individual patient data (IPD) of nine randomized trials. In order to validate the …