Retardation of neurobehavioral development and reelin down-regulation regulated by further DNA methylation in the hippocampus of the rat pups are associated with …

L Qin, W Tu, X Sun, J Zhang, Y Chen, H Zhao - Behavioural brain research, 2011 - Elsevier
It is known that early life stress has profound effects in early developing hippocampus.
Reelin is a large protein that regulates neuronal migration during embryonic development …

Early repeated maternal separation induces alterations of hippocampus reelin expression in rats

J Zhang, L Qin, H Zhao - Journal of biosciences, 2013 - Springer
The long-term effects of repeated maternal separation (MS) during early postnatal life on
reelin expression in the hippocampus of developing rats were investigated in the present …

Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats

I Palacios-García, A Lara-Vásquez, JF Montiel… - PloS one, 2015 - journals.plos.org
Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk
factor towards the development of neuropsychiatric conditions like depression, bipolar …

Early life stress stimulates hippocampal reelin gene expression in a sex‐specific manner: evidence for corticosterone‐mediated action

CM Gross, A Flubacher, S Tinnes, A Heyer… - …, 2012 - Wiley Online Library
Early life stress predisposes to the development of psychiatric disorders. In this context the
hippocampal formation is of particular interest, because it is affected by stress on the …

No effect of sustained systemic growth retardation on the distribution of Reelin-expressing interneurons in the neuron-producing hippocampal dentate gyrus in rats

T Ohishi, L Wang, B Ogawa, K Fujisawa, E Taniai… - Reproductive …, 2010 - Elsevier
Reelin signaling plays a role in neuronal migration and positioning during brain
development. To clarify the effect of systemic growth retardation on the distribution of Reelin …

Postnatal effect of embryonic neurogenesis disturbance on reelin level in organotypic cultures of rat hippocampus

C Hoareau, F Hazane, G Le Pen, MO Krebs - Brain research, 2006 - Elsevier
Despite a delayed emergence of the symptoms, schizophrenia is thought to be a late
consequence of early disturbances during development. Several reports have found …

Impairment of cognitive performance after reelin knockdown in the medial prefrontal cortex of pubertal or adult rats

J Brosda, F Dietz, M Koch - Neurobiology of disease, 2011 - Elsevier
The glycoprotein reelin is important for embryonic neuronal migration. During adulthood
reelin possibly acts as a modulator of synaptic plasticity. Several studies link reduced levels …

Expression of reelin with age in the human hippocampal formation

V Despotovski, A Vivekanandarajah, KA Waters… - …, 2021 - Wiley Online Library
Reelin plays a key role in neuronal migration and lamination in the cortex and hippocampus.
Animal studies have shown that reelin expression decreases with age. The aim of this study …

Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation

L Pujadas, A Gruart, C Bosch, L Delgado… - Journal of …, 2010 - Soc Neuroscience
Reelin, an extracellular protein essential for neural migration and lamination, is also
expressed in the adult brain. To unravel the function of this protein in the adult forebrain, we …

Perinatal asphyxia reduces the number of reelin neurons in the prelimbic cortex and deteriorates social interaction in rats

P Vázquez-Borsetti, E Peña, C Rico, M Noto… - Developmental …, 2016 - karger.com
Obstetrical complications of perinatal asphyxia (PA) can often induce lesions that, in the long-
term, manifest as schizophrenia. A deterioration of the medial prefrontal cortex (mPFC) and …