I. Introduction T HE PHARMACOLOGICAL response (dynamics) to corticosteroids is
determined by the affinity of these steroids to specific receptors at the target organ and by …

The growth of knowledge in the field of the pharmacokinetics of prednisolone/prednisone
has been slow for several reasons. First, convenient and specific methods for measuring …

Prednisone and prednisolone are used in a wide variety of diseases. The two compounds
are metabolically interconvertible; prednisolone is assumed to be the pharmacologically …

The present study was undertaken to determine whether prednisolone exhibits dose-
dependent kinetics in man. Ten normal volunteers were infused to steady state over a 7-h …

Recently, Pickup, Lowe & others (1977) demonstrated that the plasma clearance was
elevated with increasing intravenous doses of [3H] prednisolone phosphate. We have …

Kinetic data for prednisolone and prednisone have been determined following oral
administration of prednisolone over a dosage range of 5 to 200 mg in 43 subjects …

A range (approximately 0.2-2.0 micrograms/min/kg) of constant rate iv infusions of
prednisolone (as the phosphate ester) was administered to five rabbits either singly or as …

The tissue distribution and kinetics of prednisolone disposition were examined in the rabbit
under steady-state conditions. The steroid was infused to attain a range of plasma(362-4528 …

To determine the kinetics of metabolism and interconversion of prednisolone and
prednisone, the plasma levels of these synthetic glucocorticoids were measured by new …

The pharmacokinetics of prednisone and prednisolone was examined in 12 healthy male
subjects to assess the bioavailability and the parameters of reversible metabolism between …