Mechanisms by which diabetes increases cardiovascular disease

CA Gleissner, E Galkina, JL Nadler, K Ley - Drug Discovery Today …, 2007 - Elsevier
Diabetes mellitus is one of the major risk factors for cardiovascular disease which is the
leading cause of death in the United States. Increasing prevalence of diabetes and diabetic …

Molecular mechanisms linking diabetes to the accelerated development of atherosclerosis

MG Zeadin, CI Petlura, GH Werstuck - Canadian journal of diabetes, 2013 - Elsevier
Diabetes mellitus is a major independent risk factor for the development of cardiovascular
disease, and both type 1 and type 2 diabetes have been shown to accelerate the …

Pathophysiology of cardiovascular disease in diabetes mellitus

G Rodriguez-Araujo, H Nakagami - … Endocrinology & Metabolism, 2018 - journals.lww.com
Diabetes mellitus elicits cellular, epigenetic, and post-translational changes that directly or
indirectly affect the biology of the vasculature and other metabolic systems resulting in the …

The pathophysiology of cardiovascular disease in diabetes mellitus and the future of therapy

JE Thomas, JAM Foody - Journal of the cardiometabolic …, 2007 - Wiley Online Library
Diabetes mellitus is a complex disease with several metabolic abnormalities leading to
varied, interconnected endothelial and vascular dysfunction and resulting in accelerated …

Molecular targets of diabetic cardiovascular complications

FK Ahmad, Z He, GL King - Current drug targets, 2005 - ingentaconnect.com
Both the macro-and microvascular complications adversely affect the life quality of patients
with diabetes and have been the leading cause of mortality and morbidity in this population …

[HTML][HTML] Atherosclerosis, diabetes mellitus, and cancer: common epidemiology, shared mechanisms, and future management

V Katsi, I Papakonstantinou, K Tsioufis - International Journal of …, 2023 - mdpi.com
The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

[HTML][HTML] Cardiovascular disease in diabetes, beyond glucose

RH Eckel, KE Bornfeldt, IJ Goldberg - Cell metabolism, 2021 - cell.com
Despite the decades-old knowledge that diabetes mellitus is a major risk factor for
cardiovascular disease, the reasons for this association are only partially understood. While …

Emerging targets in type 2 diabetes and diabetic complications

S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

[HTML][HTML] Molecular mechanisms of vascular dysfunction and cardiovascular biomarkers in type 2 diabetes

F Paneni, S Costantino, F Cosentino - … diagnosis and therapy, 2014 - ncbi.nlm.nih.gov
Prevalence of obesity and type 2 diabetes (T2DM) is alarmingly increasing worldwide. Albeit
advances in therapy have reduced morbidity and mortality in T2DM, cardiovascular risk is far …

[HTML][HTML] Insulin resistance, hyperglycemia, and atherosclerosis

KE Bornfeldt, I Tabas - Cell metabolism, 2011 - cell.com
Progress in preventing atherosclerotic coronary artery disease (CAD) has been stalled by
the epidemic of type 2 diabetes. Further advances in this area demand a thorough …