Capsaicin was tested on peripheral fibres in vitro to determine whether evoked
depolarization or desensitization were likely to explain the antinociception observed after …

We have studied the effects of capsaicin, administered at concentrations found to be
antinociceptive in behavioural tests, on nociceptive responses evoked both in spinal dorsal …

1 We have tested the hypothesis that capsaicin‐induced activation, desensitization and
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …

The relationship of capsaicin desensitization to the antinociception produced by acute
capsaicin administration was studied in the rat. Cutaneous application of 1% capsaicin …

Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …

The effect of selective activation of nociceptive primary afferent fibers by capsaicin on a
nociceptive lower limb flexion reflex was studied in healthy human subjects. Capsaicin (1%) …

When applied to peripheral fibres in a neonatal rat tail/spinal cord preparation in vitro,
capsaicin (0.2–50 μM) induced an activation, selective desensitization and reduced …

This study was designed to investigate the antinociceptive activity of capsaicin in acute and
persistent nocifensor behavioural models and to determine whether this was mediated via a …

Recent work on the excitatory action of capsaicin on somatic and visceral afferent neurones
shows that depolarization is selective for C-fibre polymodal nociceptor afferents and …

The effect of capsaicin on the isolated sciatic nerve of rat was studied by extracellular
recording of membrane polarisation. Capsaicin depolarised the sciatic nerve, but …