Background/Aims: Endothelial cell dysfunction is the principal pathological process
underlying atherosclerotic cardiovascular disease. G protein-coupled receptor 124 …

GPR55 recognizes several lipid molecules such as lysophosphatidylinositol. GPR55
expression was reported in human monocytes. However, its role in monocyte adhesion and …

Attachment of monocytes to endothelial cells is a major event in the pathogenesis of
atherosclerosis and cardiovascular disease. As atherosclerosis is considered to be an …

G-protein-coupled receptor-35 (GPR35) has been identified as a receptor for the tryptophan
metabolite kynurenic acid (KynA) and suggested to modulate macrophage polarization in …

GPR35 (G-protein–coupled receptor 35) is a poorly characterized receptor that has
garnered increased interest as a therapeutic target through its implications in a range of …

Estrogen, the female sex hormone, is known to exert anti-inflammatory and anti-atherogenic
effects. Traditionally, estrogen effects were believed to be largely mediated through the …

Endothelial dysfunction is strongly linked with inflammatory responses, which can impact
cardiovascular disease. Recently, G protein-coupled receptor 40 (GPR40) has been …

The TCA cycle intermediate metabolite 'succinate'has been proposed as an inflammatory
mediator, influencing autoimmunity and allergic reactions, through ligation to its sensing …

Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for
development, wound healing, and tumor progression. The VEGF pathway plays …

Although human genetic studies have implicated many susceptible genes associated with
plasma lipid levels, their physiological and molecular functions are not fully characterized …