Background Opiorphin is a naturally occurring potent analgesic human peptide. It protects
enkephalins from degradation and inhibits pain perception in various acute pain models via …

BACKGROUND: Neuropathic pain represents a therapeutic challenge, and treatments with
increased efficacy and tolerability still need to be developed. Opiorphin protects …

Human opiorphin QRFSR-peptide protects enkephalins from degradation by human neutral
endopeptidase (hNEP) and aminopeptidase-N (hAP-N) and inhibits pain perception in a …

Mammalian zinc ectopeptidases play important roles in turning off neural and hormonal
peptide signals at the cell surface, notably those processing sensory information. We report …

Human opiorphin protects enkephalins from degradation by human neutral endopeptidase
and aminopeptidase-N and inhibits pain perception in various behavioral rodent models of …

Severe pain occurs in the context of many diseases and conditions and is a leading cause of
disability. Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand of the N/OFQ peptide …

Background: Opiorphin is an endogenous human peptide regulator of enkephalin
bioavailability. It inhibits enkephalin-inactivating ectopeptidases to produce analgesia and …

Opioid peptides are potent analgesics with therapeutic potential in the treatment of acute
and chronic pain. Their efficacy is limited by peptidases (enkephalinases). Opiorphin …

Nociceptin/orphanin FQ peptide receptor (NOP) agonists produce antinociceptive effects in
animal models after spinal administration and potentiate μ-opioid receptor (MOP)-mediated …

Chemical modifications of nociceptin/orphanin FQ (N/OFQ) peptide that result in increased
potency and resistance to degradation have recently lead to the discovery of [(pF) Phe 4 Aib …