Prostate cancer is the most commonly diagnosed tumor in men in the United States. Patients
with hormone-refractory prostate cancer are often treated with paclitaxel, but most of them …

We have demonstrated that phenylacetate (PA)-induced cell cycle arrest in human prostate
cancer is mediated by increase of p27. In this study, we further investigated the mechanism …

More than half of all cancer patients receive chemotherapy, however, some of them easily
acquire drug resistance. Resistance to chemotherapy has become a massive obstacle to …

Prostate cancer is the most frequently diagnosed tumor in men and the second most
common cause of cancer-related death for males in the United States. It has been shown …

Androgen ablation therapy is the primary treatment for metastatic prostate cancer. However,
80-90% of the patients who receive androgen ablation therapy ultimately develop recurrent …

Purpose: Prostate carcinomas show a low level of the cell cycle inhibitor p27, which
correlates with tumor aggressiveness. In tumors p27 is of the WT species and its …

Osteosarcoma (OS) is a common bone tumor that mainly affects children and young adults.
S-phase kinase‑associated protein 2 (Skp2) has been characterized to play a critical …

BACKGROUND: In several human cancers, overexpression of Skp2 (S-phase kinase
associated protein 2), which targets p27 for degradation, portends a poorer prognosis. We …

SKP2, an F-box protein of the SCF type of the E3 ubiquitin ligase complex, plays an
important function in driving tumorigenesis through the destruction of numerous tumor …

The F box protein Skp2 is oncogenic, and its frequent amplification and overexpression
correlate with the grade of malignancy of certain tumors. Conversely, depletion of Skp2 …