In vitro assessment of the anti-trypanosomal and anti-microtubule properties of novel imido-substituted 1, 4-naphthoquinone derivatives
MH Khraiwesh - 2011 - search.proquest.com
American trypanosomiasis, caused by the protozoan Trypanosoma cruzi, is a potentially
fatal disease in Central and South America. Nifurtimox, one of the drugs of choice, has many …
fatal disease in Central and South America. Nifurtimox, one of the drugs of choice, has many …
Antitrypanosomal Activities and Cytotoxicity of Some Novel Imido-substituted 1, 4-Naphthoquinone Derivatives
C Lee - Archives of Pharmacal Research, 2011 - dh.howard.edu
The antitrypanosomal activities, cytotoxicity, and selectivity indices of eleven imido-
substituted 1, 4-naphthoquinone derivatives and nifurtimox have been studied. Compared to …
substituted 1, 4-naphthoquinone derivatives and nifurtimox have been studied. Compared to …
Antitrypanosomal activities and cytotoxicity of some novel imidosubstituted 1, 4-naphthoquinone derivatives
MH Khraiwesh, CM Lee, Y Brandy, ES Akinboye… - Archives of pharmacal …, 2012 - Springer
The antitrypanosomal activities, cytotoxicity, and selectivity indices of eleven imido-
substituted 1, 4-naphthoquinone derivatives and nifurtimox have been studied. Compared to …
substituted 1, 4-naphthoquinone derivatives and nifurtimox have been studied. Compared to …
Naphthoquinone derivatives exhibit apoptosis-like effect and anti-trypanosomal activity against Trypanosoma evansi
Trypanosoma evansi is an extracellular flagellate blood protozoan parasite and an
etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and …
etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and …
2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities
I Sieveking, P Thomas, JC Estévez, N Quiñones… - Bioorganic & medicinal …, 2014 - Elsevier
A series of new 2-aminonaphthoquinones and related compounds were synthesized and
evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited …
evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited …
Growth inhibitory effect of naphthofuran and naphthofuranquinone derivatives on Trypanosoma cruzi epimastigotes
R Ribeiro-Rodrigues, WG Dos Santos… - Bioorganic & Medicinal …, 1995 - Elsevier
Synthetic and natural naphthofuranquinones were tested in vitro against three Trypanosoma
cruzi strains with different drug susceptibility to nifurtimox and benznidazole in vivo. Four …
cruzi strains with different drug susceptibility to nifurtimox and benznidazole in vivo. Four …
In vitro and In vivo Biological Activity of Two Aryloxy-naphthoquinones in Mice Infected with Trypanosoma cruzi Strains.
K Vázquez, A Moreno-Rodríguez… - … (United Arab Emirates …, 2024 - europepmc.org
Background Chagas disease, a condition caused by Trypanosoma cruzi, is an endemic
disease in Latin American countries that affects approximately eight million people …
disease in Latin American countries that affects approximately eight million people …
Efficacy of 2-hydroxy-3-phenylsulfanylmethyl-[1, 4]-naphthoquinone derivatives against different Trypanosoma cruzi discrete type units: Identification of a promising hit …
The limited efficacy of benznidazole (Bz) indicated by failures of current Phase II clinical
trials emphasizes the urgent need to identify new drugs with improved safety and efficacy for …
trials emphasizes the urgent need to identify new drugs with improved safety and efficacy for …
Antitrypanosomal activity of 1, 2-dihydroquinolin-6-ols and their ester derivatives
The current chemotherapy for second stage human African trypanosomiasis is
unsatisfactory. A synthetic optimization study based on the lead antitrypanosomal compound …
unsatisfactory. A synthetic optimization study based on the lead antitrypanosomal compound …
Natural naphthoquinones and their derivatives as potential drug molecules against trypanosome parasites
Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …
resources and several of naphthoquinone derivatives with diverse structural motif have been …