The available treatment for the prevention and cure of Chagas disease, caused by the
protozoan Trypanosoma cruzi, is still unsatisfactory. Thus, there is an urgent need to …

Human African trypanosomiasis (HAT) is a deadly disease in need of new
chemotherapeutics that can cross into the central nervous system. We previously reported …

In a screening of 65 derivatives of natural quinones using bloodstream trypomastigotes of
Trypanosoma cruzi, the 3 naphthoimidazoles derived from β-lapachone–N1, N2 and N3 …

Chagas disease is caused by the parasite Trypanosoma cruzi and affects approximately
eight million individuals in the developing world; it is also classified as a neglected tropical …

For decades, only two nitroheterocyclic drugs have been used as therapeutic agents for
Chagas disease. However, these drugs present limited effectiveness during the chronic …

Abstract Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by
the parasitic protozoan Trypanosoma brucei (T. b.), and affects communities in sub-Saharan …

About 160 fluoroquinolones and derivatives were tested for antitrypanosomal activity in a
drug sensitivity assay followed by fluorometric evaluation. The most active quinolone …

Naphtho [2, 3-b] thiophen-4, 9-quinone and five derivatives were prepared using the Friedel-
Crafts reaction and tandem-lithiation of aromatic diethylamides. These quinones were …

Background: Chagas disease affects about 7 million people worldwide. Only two drugs are
currently available for the treatment for this parasite disease, namely, benznidazol (Bzn) and …

Chagas disease, also called American trypanosomiasis, is a parasitic disease caused by
Trypanosoma cruzi (T. cruzi). Recent findings have underscored the abundance of the …