A set of new aryloxy-quinones were synthesized and evaluated in vitro against the
epimastigote form of Trypanosoma cruzi and their unspecific cytotoxicity was tested on …

Current chemotherapy drugs for Chagas' disease are insufficient due to their limited efficacy;
however, anti-trypanosomal agents have recently shown promise. As such, synthetic …

Several quinoline derivatives incorporating arylnitro and aminochalcone moieties were
synthesized and evaluated in vitro against a broad panel of trypanosomatid protozoan …

Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids
Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively, are considered …

Trypanosoma cruzi is the etiological agent of Chagas disease, affecting approximately 10
million people in the Americas and with some 40 million people at risk. The objective of this …

Chagas' disease, caused by Trypanosoma cruzi (T. cruzi), is one of the most serious
parasitic diseases in Latin America. The currently available chemotherapy, based on …

In this study, a series of 22 pre-synthesized 7-chloro-4-amino (oxy) quinoline derivatives
was assayed in vitro as potential antichagasic agents. A primary screening against …

A small library of 2-phenoxy-1, 4-naphthoquinone and 2-phenoxy-1, 4-anthraquinone
derivatives was initially developed to optimize the antitrypanosomatid profile of the …

Imidazolium salts are best known for their applications in organic synthesis as room-
temperature ionic liquids, or as precursors of stable carbenes, but they also show important …

The discovery of new secondary metabolites from natural origins has become more
challenging in natural products research. Different approaches have been applied to target …