Imidazolium compounds are active against all stages of Trypanosoma cruzi

P Faral-Tello, M Liang, G Mahler, P Wipf… - International journal of …, 2014 - Elsevier
Imidazolium salts are best known for their applications in organic synthesis as room-
temperature ionic liquids, or as precursors of stable carbenes, but they also show important …

Synthesis and structure–activity relationships of new quinolone-type molecules against Trypanosoma brucei

G Hiltensperger, NG Jones, S Niedermeier… - Journal of medicinal …, 2012 - ACS Publications
Human African trypanosomiasis (HAT) or sleeping sickness is caused by two subspecies of
Trypanosoma brucei, Trypanosoma brucei gambiense, and Trypanosoma brucei …

Novel Design of Drugs for American Trypanosomiasis via Homology Modeling and Pharmacophore Analysis of the Binding of Naphthoquinone Derivatives with …

CO Ogindo - 2016 - search.proquest.com
Chagas, also called American trypanosomiasis, is a parasitic disease caused by
Trypanosoma cruzi. Recent findings underscored the abundance of the causative organism …

[HTML][HTML] Biological activities of 1, 4-naphthoquinones derivatives against T. cruzi and L. amazonensis

AO Silva, RS Lopes, AAS Naujorks… - … de Ciencias Químico …, 2022 - scielo.org.co
SUMMARY Introduction: Chagas disease and Leishmaniasis are neglected diseases
caused by the Trypanosoma cruzi and kentoplastid parasites Leishmania spp. Parasitic …

Targeted Isolation of Anti-Trypanosomal Naphthofuran-Quinone Compounds from the Mangrove Plant Avicennia lanata

NW Mazlan, C Clements, RA Edrada-Ebel - Marine drugs, 2020 - mdpi.com
The discovery of new secondary metabolites from natural origins has become more
challenging in natural products research. Different approaches have been applied to target …

[PDF][PDF] An aromatic imidazoline derived from chloroquinoline triggers cell cycle arrest and inhibits with high selectivity the Trypanosoma cruzi mammalian host-cells …

RIC Hernández, RMBM Girard… - PL o S Neglected …, 2021 - repositorio.usp.br
Trypanosoma cruzi is a hemoflagellated parasite causing Chagas disease, which affects 6–
8 million people in the Americas. More than one hundred years after the description of this …

New oxirane derivatives of 1, 4-naphthoquinones and their evaluation against T. cruzi epimastigote forms

PF Carneiro, SB do Nascimento, AV Pinto… - Bioorganic & medicinal …, 2012 - Elsevier
New oxirane derivatives were synthesized using six naphthoquinones as the starting
materials. Our biological results showed that these oxiranes acted as trypanocidal agents …

Assessment of the Activity of Nitroisoxazole Derivatives against Trypanosoma cruzi

M Moncada-Basualto, J Saavedra-Olavarría… - Molecules, 2024 - mdpi.com
The development of new compounds to treat Chagas disease is imperative due to the
adverse effects of current drugs and their low efficacy in the chronic phase. This study aims …

A fluorinated phenylbenzothiazole arrests the Trypanosoma cruzi cell cycle and diminishes the infection of mammalian host cells

RI Cuevas-Hernández, RMBM Girard… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
Chagas disease (CD) is a human infection caused by Trypanosoma cruzi. CD was
traditionally endemic to the Americas; however, due to migration it has spread to countries …

A Quinoxaline Derivative as a Potent Chemotherapeutic Agent, Alone or in Combination with Benznidazole, against Trypanosoma cruzi

JHS Rodrigues, T Ueda-Nakamura, AG Correa… - PloS one, 2014 - journals.plos.org
Background Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi
that affects millions of people, mainly in Latin America where it is considered endemic. The …