Polo, the founding member of the family of polo-like kinases (Plks) was identified in
aDrosphila screen for mutants affecting spindle pole behavior. 1 Several mutants …

Abstract Polo-like kinase-1 (Plk1) has a pivotal role in cell proliferation and is considered a
potential target for anticancer therapy. The noncatalytic polo-box domain (PBD) of Plk1 …

Polo‐like kinases (Plks) are the key regulators of cell cycle progression, the members of
which share a kinase domain and a polo‐box domain (PBD) that serves as a protein …

Mitosis is coordinated by carefully controlled phosphorylation and ubiquitin-mediated
proteolysis. Polo-like kinase 1 (Plk1) plays a central role in regulating mitosis and …

Members of the polo subfamily of protein kinases play pivotal roles in cell proliferation. In
addition to the kinase domain, polo kinases have a strikingly conserved sequence in the …

Precise control over cell cycle mechanics is crucial for maintenance of genomic integrity
during the propagation of daughter cells. Knowledge of the functions and relationships …

Mammalian polo-like kinase 1 (Plk1) has been studied intensively as a key element in
regulating diverse mitotic events during M-phase progression. Plk1 is spatially regulated …

Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for
cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of …

Polo-like kinase (PLK) 2 is an evolutionarily conserved serine/threonine kinase that shares
the n-terminal kinase catalytic domain and the C-terminal Polo Box Domain (PBD) with other …

Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis
and cytokinesis. In agreement with a broad range of proposed functions during cell division …