Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-
like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region …

Abstract Polo‐like kinase 1 (Plk1), a validated cancer target, harbors a protein–protein
interaction domain referred to as the polo‐box domain (PBD), in addition to its enzymatic …

Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for
cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of …

Polo like kinase 1 (Plk1) is a key player in orchestrating the wide variety of cell-cycle events
ranging from centrosome maturation, mitotic entry, checkpoint recovery, transcriptional …

Mammalian polo-like kinase 1 (Plk1) acts at various stages in early and late mitosis. Plk1
localizes at the centrosome and maintains this position through mitosis. Thereafter Plk1 …

Drosophila melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential
roles during cell division. Members of the Polo-like kinase (Plk) family contain an N-terminal …

PLK1 (polo-like kinase 1) is a key mitotic kinase and a therapeutic target in the treatment of
proliferative diseases. Here we investigate the relative substrate specificity and …

Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. New
techniques, including the application of small-molecule inhibitors, have greatly expanded …

Polo-like kinase 1 (Plk1) has multiple important functions during M-phase progression. In
addition to a catalytic domain, Plk1 possesses a phosphopeptide-binding motif, the polo-box …

Polo-like kinase 1 (Plk1) appears to be an attractive target for anticancer therapy. In this
issue of Chemistry & Biology, Reindl et al.(2008) describe the identification of a small …