Polo-like kinase (Plk) is a cell cycle-regulated, cyclin-independent serine/threonine protein
kinase. Plk protein levels are low or undetectable in terminally differentiated cells and …

Polo-like kinase 1 (Plk1) is an essential protein kinase that promotes faithful mitotic
progression in eukaryotes. The subcellular localization and substrate interactions of Plk1 are …

Present in organisms ranging from yeast to man, homologues of the Drosophila Polo kinase
control multiple stages of cell division. At the onset of mitosis, Polo-like kinases (Plks) …

Abstract Polo-like kinase 1 (PLK1) is a crucial regulator of cell cycle progression. It is
established that the activation of PLK1 depends on the coordinated action of Aurora-A and …

Abstract Polo-like kinase 1 (Plk1) plays key roles in regulating various mitotic processes that
are critical for cellular proliferation. A growing body of evidence suggests that Plk1 …

Polo-like kinase-1 (Plk1) is phosphorylated on Thr210 for activation during mitosis. Here, we
investigated the question of which kinase (s) is the specific upstream kinase of mitotic Plk1 …

The small family of polo-like kinases (Plks) includes Cdc5 from Saccharomyces cerevisiae,
Plo1 from Schizosaccharomyces pombe, Polo from Drosophila melanogaster and the four …

Polo-like kinase 1 (Plk1) is a core regulator of cell division and an emerging target for cancer
therapy. Pharmacologic inhibitors of Plk1 exist but affect other kinases, complicating their in …

Purpurogallin (PPG, 2) and poloxin (3) have been reported as inhibitors of the polo-box
domain (PBD) of human polo-like kinase 1. However, our experimental results demonstrated …

Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of
genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in …