Local regulation of hematopoietic differentiation in the marrow requires close interactions
with components of the microenvironment. In this study, we explored the capacity of human …

Growth and differentiation of hematopoietic stem cells occur in close contact with the cells
and extracellular-matrix (ECM) proteins of the hematopoietic microenvironment. We …

One of the mechanisms by which normal hematopoietic progenitor cells remain localized
within the bone marrow microenvironment is likely to involve adhesion of these cells to …

The hematopoietic microenvironment is a complex structure in which stem cells, progenitor
cells, stromal cells, growth factors, and extracellular matrix (ECM) molecules each interact to …

We have reviewed some aspects of the production, distribution, and organization of
fibronectin in the bone marrow ECM and discussed HSC-fibronectin interactions. Many …

Using a novel coverslip-transfer culture technique, we recently demonstrated that primitive
erythroid burst-forming units (BFU-E) can migrate, proliferate, and differentiate in intimate …

The binding of late stage erythroid cells to fibronectin (FN) has been well characterized and
is believed to be critical for the terminal stages of erythroid differentiation, but the adhesive …

Human hemopoietic blast colony-forming cells (BI-CFCs) recognize and adhere to the
extracellular matrix (ECM) produced by marrow-derived stromal cells in vitro. We have …

Human bone marrow-derived CD34+ cells were analyzed for the expression of the beta 1-
family of integrin adhesion molecules. Integrin alpha 4 beta 1 was consistently expressed by …

Hematopoietic microenvironment is comprised of an admixture of several adherent cell
types including fibroblasts, reticular adventitial cells, and marcophages. The biologic …