The prognostic significance of epidermal growth factor receptor (EGFR) expression in lung
cancer and, more importantly, its ability to predict response to anti-EGFR therapies, are …

Epidermal growth factor receptor is a trans-membrane glycoprotein with an extracellular
epidermal growth factor binding domain and an intracellular tyrosine kinase domain that …

Lung cancer, like many other epithelial malignancies, is thought to be the outcome of
genetic and epigenetic changes that result in a constellation of phenotypic abnormalities in …

The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Background: It is thought that overexpression of epidermal growth factor receptor (EGFR) in
non-small cell lung cancer (NSCLC) might compromise patient survival, presumably by …

In the last 5 years the epidermal growth factor receptor (EGFR) has emerged as one of the
most important targets for drug development in oncology. Monoclonal antibodies targeting …

Non-small cell lung cancer (NSCLC) is the major cause of cancer-related deaths in the USA
and worldwide. Most patients present with advanced disease, and treatment options for …

The EGFR pathway has emerged as a key target in non-small-cell lung cancer. EGF
receptor (EGFR) inhibition in non-small-cell lung cancer is achieved via small molecular …

Purpose: The epidermal growth factor receptor (EGFR) is frequently overexpressed in non–
small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic …

The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, including
EGFR, HER2/erbB2, and HER3/erbB3, is an attractive target for antitumor strategies …