Bayesian hidden Markov modeling of array CGH data

S Guha, Y Li, D Neuberg - Journal of the American Statistical …, 2008 - Taylor & Francis
Genomic alterations have been linked to the development and progression of cancer. The
technique of comparative genomic hybridization (CGH) yields data consisting of …

Bayesian random segmentation models to identify shared copy number aberrations for array CGH data

V Baladandayuthapani, Y Ji, R Talluri… - Journal of the …, 2010 - Taylor & Francis
Array-based comparative genomic hybridization (aCGH) is a high-resolution, high-
throughput technique for studying the genetic basis of cancer. The resulting data consist of …

Hidden Markov models approach to the analysis of array CGH data

J Fridlyand, AM Snijders, D Pinkel, DG Albertson… - Journal of multivariate …, 2004 - Elsevier
The development of solid tumors is associated with acquisition of complex genetic
alterations, indicating that failures in the mechanisms that maintain the integrity of the …

Bayesian hidden Markov modeling of array CGH data

S Guha, Y Li, D Neuberg - Harvard University, Paper, 2006 - api.taylorfrancis.com
The normal genomic code of human females consists of 23 matched pairs of chromosomes.
The genomic code of human males consists of 22 matched pairs of autosomal …

Continuous-index hidden Markov modelling of array CGH copy number data

S Stjernqvist, T Rydén, M Sköld, J Staaf - Bioinformatics, 2007 - academic.oup.com
Motivation: In recent years, a range of techniques for analysis and segmentation of array
comparative genomic hybridization (aCGH) data have been proposed. For array designs in …

A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations

DA Engler, G Mohapatra, DN Louis, RA Betensky - Biostatistics, 2006 - academic.oup.com
DNA sequence copy number has been shown to be associated with cancer development
and progression. Array-based comparative genomic hybridization (aCGH) is a recent …

Stochastic segmentation models for array-based comparative genomic hybridization data analysis

TL Lai, H Xing, N Zhang - Biostatistics, 2008 - academic.oup.com
Array-based comparative genomic hybridization (array-CGH) is a high throughput, high
resolution technique for studying the genetics of cancer. Analysis of array-CGH data typically …

Analysis of array CGH data for cancer studies using fused quantile regression

Y Li, J Zhu - Bioinformatics, 2007 - academic.oup.com
Motivation: The identification of DNA copy number changes provides insights that may
advance our understanding of initiation and progression of cancer. Array-based comparative …

Integrating copy number polymorphisms into array CGH analysis using a robust HMM

SP Shah, X Xuan, RJ DeLeeuw, M Khojasteh… - …, 2006 - academic.oup.com
Motivation: Array comparative genomic hybridization (aCGH) is a pervasive technique used
to identify chromosomal aberrations in human diseases, including cancer. Aberrations are …

A versatile statistical analysis algorithm to detect genome copy number variation

RS Daruwala, A Rudra, H Ostrer… - Proceedings of the …, 2004 - National Acad Sciences
We have developed a versatile statistical analysis algorithm for the detection of genomic
aberrations in human cancer cell lines. The algorithm analyzes genomic data obtained from …