Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this
study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to …

Introduction Cigarette smoke is a profound pro-inflammatory stimulus that contributes to
acute lung injuries and to chronic lung disease including COPD (emphysema and chronic …

Inflammation is a protective response to injury, but it can become chronic, leading to tissue
damage and disease. Cigarette smoke causes multiple inflammatory diseases, which …

Inappropriate neutrophil activation contributes to the pathogenesis of acute lung injury (ALI).
Apoptosis is essential for removal of neutrophils from inflamed tissues and timely resolution …

Background Cigarette smoke induced airway inflammation plays a role in pathogenesis of
airway inflammation. Resolvin-D1 derived from omega-3 polyunsaturated fatty acids is an …

Cardiac fibroblasts (CFs) have a key role in the inflammatory response after cardiac injury
and are necessary for wound healing. Resolvins are potent agonists that control the duration …

Effective clearance of apoptotic cells by macrophages, termed efferocytosis, is pre-requisite
for successful resolution of inflammation, and drives macrophage emigration to the draining …

Fibroblasts, far frombeing merely bystander cells, are known to play a specific role in
inflammation resolution after an acute injury. As the endogenous “braking signal,” resolvins …

Endogenous mediators, such as RvE1 (resolvin E1), promote resolution of an inflammatory
response and have potential as novel therapeutic agents. In the present study, we …

Chronic obstructive pulmonary disease is characterized, in part, by chronic inflammation that
persists even after smoking cessation, suggesting that a failure to resolve inflammation plays …