Management of neonates with trisomy 18, which is a common chromosomal abnormality, is
controversial. Withholding or withdrawal of intensive treatment (cesarean, resuscitation …

Management of neonates with trisomy 18 is controversial, supposedly due to the prognosis
and the lack of precise clinical information concerning efficacy of treatment. To delineate the …

We conducted a questionnaire‐based study in collaboration with a Japanese trisomy 18
parental support group. Sixty‐five children (female, 68%) with full trisomy 18 were evaluated …

The effects of medical and surgical interventions on the survival of patients with trisomy 18
have been reported, leading to changes in perinatal management and decision‐making …

Management of children with trisomy 13 (T13) is controversial because of a paucity of
evidence of the natural history, especially focusing on efficacy of treatment. There has been …

Trisomy 18, Edwards syndrome, is the third most common chromosome disorder in liveborn
infants after the Down and 22q deletion syndromes. This condition occurs in about 1 in …

Two relevant and noteworthy studies are published together in this issue of the Journal
[Meyer et al., 2016; Subramaniam et al., 2016]. Both articles discuss an important and timely …

Intensive cardiac management such as pharmacological intervention for ductal patency
(indomethacin and/or mefenamic acid for closure and prostaglandin E1 for maintenance) …

The prognosis of trisomy 18 is lethal, but recently some long-term survival cases have been
recognized. We report here the mortality rate of trisomy 18 based on our hospital data and …

The aim of this study was to clarify the effects of gestational age and birth weight on
outcomes of the infants. Medical records of 36 infants with trisomy 18 admitted to Tokyo …