Xenobiotics: interaction with the intestinal microflora
K Lu, R Mahbub, JG Fox - ILAR journal, 2015 - academic.oup.com
The human body is host to 100 trillion gut microbes, approximately 10-times more than all
human cells. It is estimated that the approximately 500–1000 species residing in the human …
human cells. It is estimated that the approximately 500–1000 species residing in the human …
Chemical transformation of xenobiotics by the human gut microbiota
N Koppel, V Maini Rekdal, EP Balskus - Science, 2017 - science.org
BACKGROUND Humans ingest a multitude of small molecules that are foreign to the body
(xenobiotics), including dietary components, environmental chemicals, and …
(xenobiotics), including dietary components, environmental chemicals, and …
Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota
AE Lindell, M Zimmermann-Kogadeeva… - Nature Reviews …, 2022 - nature.com
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …
Studies of xenobiotic-induced gut microbiota dysbiosis: from correlation to mechanisms
Environmental chemicals can alter gut microbial community composition, known as
dysbiosis. However, the gut microbiota is a highly dynamic system and its functions are still …
dysbiosis. However, the gut microbiota is a highly dynamic system and its functions are still …
The impact of environmental chemicals on the gut microbiome
Since the surge of microbiome research in the last decade, many studies have provided
insight into the causes and consequences of changes in the gut microbiota. Among the …
insight into the causes and consequences of changes in the gut microbiota. Among the …
[HTML][HTML] The gut microbiome: an orchestrator of xenobiotic metabolism
SL Collins, AD Patterson - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism.
The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter …
The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter …
Chemical metabolism of xenobiotics by gut microbiota
R Nakov, T Velikova - Current Drug Metabolism, 2020 - ingentaconnect.com
Among the gut microbiota's newly explored roles in human biology is the ability to modify the
chemical structures of foreign compounds (xenobiotics). A growing body of evidence has …
chemical structures of foreign compounds (xenobiotics). A growing body of evidence has …
Gut homeostasis and microbiota under attack: Impact of the different types of food contaminants on gut health
Food contaminants represent food constituents that are accidentally introduced during food
preparation cycle. In addition to their direct toxic effects on human health at different levels …
preparation cycle. In addition to their direct toxic effects on human health at different levels …
[HTML][HTML] Xenobiotics shape the physiology and gene expression of the active human gut microbiome
The human gut contains trillions of microorganisms that influence our health by metabolizing
xenobiotics, including host-targeted drugs and antibiotics. Recent efforts have characterized …
xenobiotics, including host-targeted drugs and antibiotics. Recent efforts have characterized …
Deciphering the chemical lexicon of host–gut microbiota interactions
GR Nicolas, PV Chang - Trends in pharmacological sciences, 2019 - cell.com
The human intestine harbors an immense, diverse, and critical population of bacteria that
has effects on numerous aspects of host physiology, immunity, and disease. Emerging …
has effects on numerous aspects of host physiology, immunity, and disease. Emerging …