Xenobiotics: interaction with the intestinal microflora

K Lu, R Mahbub, JG Fox - ILAR journal, 2015 - academic.oup.com
The human body is host to 100 trillion gut microbes, approximately 10-times more than all
human cells. It is estimated that the approximately 500–1000 species residing in the human …

Chemical transformation of xenobiotics by the human gut microbiota

N Koppel, V Maini Rekdal, EP Balskus - Science, 2017 - science.org
BACKGROUND Humans ingest a multitude of small molecules that are foreign to the body
(xenobiotics), including dietary components, environmental chemicals, and …

Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota

AE Lindell, M Zimmermann-Kogadeeva… - Nature Reviews …, 2022 - nature.com
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

Studies of xenobiotic-induced gut microbiota dysbiosis: from correlation to mechanisms

L Chi, P Tu, H Ru, K Lu - Gut Microbes, 2021 - Taylor & Francis
Environmental chemicals can alter gut microbial community composition, known as
dysbiosis. However, the gut microbiota is a highly dynamic system and its functions are still …

The impact of environmental chemicals on the gut microbiome

K Chiu, G Warner, RA Nowak, JA Flaws… - Toxicological …, 2020 - academic.oup.com
Since the surge of microbiome research in the last decade, many studies have provided
insight into the causes and consequences of changes in the gut microbiota. Among the …

[HTML][HTML] The gut microbiome: an orchestrator of xenobiotic metabolism

SL Collins, AD Patterson - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism.
The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter …

Chemical metabolism of xenobiotics by gut microbiota

R Nakov, T Velikova - Current Drug Metabolism, 2020 - ingentaconnect.com
Among the gut microbiota's newly explored roles in human biology is the ability to modify the
chemical structures of foreign compounds (xenobiotics). A growing body of evidence has …

Gut homeostasis and microbiota under attack: Impact of the different types of food contaminants on gut health

MM Elmassry, A Zayed, MA Farag - Critical Reviews in Food …, 2022 - Taylor & Francis
Food contaminants represent food constituents that are accidentally introduced during food
preparation cycle. In addition to their direct toxic effects on human health at different levels …

[HTML][HTML] Xenobiotics shape the physiology and gene expression of the active human gut microbiome

CF Maurice, HJ Haiser, PJ Turnbaugh - Cell, 2013 - cell.com
The human gut contains trillions of microorganisms that influence our health by metabolizing
xenobiotics, including host-targeted drugs and antibiotics. Recent efforts have characterized …

Deciphering the chemical lexicon of host–gut microbiota interactions

GR Nicolas, PV Chang - Trends in pharmacological sciences, 2019 - cell.com
The human intestine harbors an immense, diverse, and critical population of bacteria that
has effects on numerous aspects of host physiology, immunity, and disease. Emerging …