Learning and memory storage are the fundamental activities of the brain. Aberrant
expression of synaptic molecular markers has been linked to memory impairment in AD …

Oxidative stress and mitochondrial dysfunction are implicated in the neuronal cell death that
occurs in physiological settings and in neurodegenerative disorders. In Alzheimer's disease …

Substantial evidence supports the hypothesis that oxygen free radicals are involved in
various neurodegenerative disorders. To assess the presence of oxidative stress in …

Membrane lipid peroxidation and oxidative modification of various membrane and
associated proteins (eg, receptors, ion transporters and channels, and signal transduction …

Proteins play an important role in normal structure and function of the cells. Oxidative
modification of proteins may greatly alter the structure and may subsequently lead to loss of …

OXYGEN is essential for the survival of all aerobic life forms. However, oxidative
phosphorylation through the mitochondrial electron transport chain (ETC) also generates …

Oxidative stress and mitochondrial damage are implicated in the evolution of
neurodegenerative diseases. Increased oxidative damage in specific brain regions during …

Alzheimer's disease is a multifactorial, progressive, age-related neurodegenerative disease.
In familial Alzheimer's disease, Aβ is excessively produced and deposited because of …

Oxidative stress is an early hallmark in neurodegenerative disorders such as Alzheimer's
and Parkinson's diseases. However, the critical biochemical effector mechanisms of …

Oxidative stress is observed in Alzheimer's disease (AD) brain, including protein oxidation
and lipid peroxidation. One of the major pathological hallmarks of AD is the brain deposition …