Aims: Synaptic deficits are known to underlie the cognitive dysfunction seen in Alzheimer's
disease (AD). Generation of reactive oxygen species (ROS) by β-amyloid has also been …

Oxidative stress imparted by reactive oxygen species (ROS) is implicated in the
pathogenesis of Alzheimer's disease (AD). Given that amyloid β (Aβ) itself generates ROS …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases
responsible for progressive dementia. Deposition of amyloid-β (Aβ) in the brain is the most …

The beta amyloid peptide (Aβ), the major protein component of brain senile plaques in
Alzheimer's disease, is known to be directly responsible for the production of free radicals …

The etiology of astrocyte dysfunction is not well understood even though neuronal defects
have been extensively studied in a variety of neuronal degenerative diseases. Astrocyte …

Altered redox dynamics contribute to physiological aging and Parkinson's disease (PD). This
is reflected in the substantia nigra (SN) of PD patients as lowered antioxidant levels and …

Aging is a natural process that includes several changes that gradually make organisms
degenerate and die. Harman's theory proposes that aging is a consequence of the …

Senile plaques are neuropathological manifestations in Alzheimer's disease (AD) and are
composed mainly of extracellular deposits of amyloid β‐peptide (Aβ). Various data suggest …

Recent studies indicate that mitochondrial electron transport dysfunction is involved in
various neurodegenerative diseases, including Alzheimer's disease. Although much …

Alzheimer's disease (AD) is associated with accumulations of amyloid-β (Aβ) peptides,
oxidative damage, mitochondrial dysfunction, neurodegeneration, and dementia. The …