Background The risk of sexual transmission of HIV-1 is strongly associated with the level of
HIV-1 RNA in plasma making reduction in HIV-1 plasma levels an important target for HIV-1 …

Objective: To estimate the impact of small changes in plasma levels of HIV-1 RNA on the risk
of heterosexual transmission or disease progression to an AIDS-defining event or death …

High plasma HIV-1 RNA concentrations are associated with an increased risk of HIV-1
transmission. Although plasma and genital HIV-1 RNA concentrations are correlated, no …

Summary Background High plasma HIV-1 RNA concentrations are associated with
increased risk of HIV-1 transmission. Initiation of antiretroviral therapy (ART) reduces plasma …

Objective: Combination antiretroviral therapy (ART) decreases the risk of sexual HIV
transmission by suppressing blood and genital HIV RNA concentrations. We sought to …

Background Host genetic factors may be important determinants of HIV-1 sexual acquisition.
We performed a genome-wide association study (GWAS) for host genetic variants modifying …

Background Antiretroviral therapy (ART) markedly reduces HIV transmission, and testing
and treatment programs have been advocated as a method for decreasing transmission at …

Background The risk of sexual transmission of HIV from individuals with low-level HIV
viraemia receiving antiretroviral therapy (ART) has important public health implications …

Background It is unclear whether there are differences between men and women with
human immunodeficiency virus type 1 (HIV-1) infection in the plasma level of viral RNA (the …

Background The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III,
placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV …