Modern therapies in atopic dermatitis: biologics and small molecule drugs

M Worm, W Francuzik, M Kraft… - JDDG: Journal der …, 2020 - Wiley Online Library
Atopic dermatitis (AD) is a frequent, chronic remittent skin disease. The pathophysiology of
AD has been increasingly understood within the last years, which may help to identify …

Dupilumab in atopic dermatitis: rationale, latest evidence and place in therapy

LFM Ariëns, DS Bakker… - … advances in chronic …, 2018 - journals.sagepub.com
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. The
prevalence of AD is increasing and is currently estimated at 10–20% in adults worldwide. In …

[HTML][HTML] Efficacy of dupilumab on different phenotypes of atopic dermatitis: one-year experience of 221 patients

S Tavecchio, L Angileri, F Pozzo Giuffrida… - Journal of clinical …, 2020 - mdpi.com
Background: The clinical features of adult-onset atopic dermatitis (AD) are heterogeneous
and the diagnosis can be a challenge. A new biologic drug (dupilumab) has been approved …

Biologics for treatment of atopic dermatitis: current status and future prospect

T Ratchataswan, TM Banzon, JP Thyssen… - The Journal of Allergy …, 2021 - Elsevier
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intense
pruritus and recurrent eczematous lesions that significantly impair quality of life. It is a …

Dupilumab for Atopic Dermatitis—From Clinical Trials to Molecular and Cellular Mechanisms

B Cabanillas - Dermatitis®, 2023 - liebertpub.com
Dupilumab is a monoclonal antibody that represents the first approved targeted biological
therapy for adults, adolescents, and children older than 6 years with moderate-to-severe …

Emerging systemic therapeutic biologics and small molecules for atopic dermatitis: how to decide which treatment is right for your patients

J Ahn, EE Grinich, Y Choi, E Guttman-Yassky… - The Journal of Allergy …, 2021 - Elsevier
The evolving discoveries in atopic dermatitis (AD) broaden our understanding of the
pathogenesis of the disease and, above all, enable better management for patients …

[HTML][HTML] The new era of biologics in atopic dermatitis: a review

S Schneider, L Li, A Zink - Dermatology Practical & Conceptual, 2021 - ncbi.nlm.nih.gov
Atopic dermatitis (AD) is a prevalent inflammatory skin disorder affecting all age and ethnic
groups. The age-dependent varying appearance and extent of pruritic lesions are …

Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy

AM D'Erme, M Romanelli… - Drug Design, Development …, 2017 - Taylor & Francis
Atopic dermatitis (AD) is among the most common inflammatory skin diseases in children
and adults in industrialized countries. Up to one-third of adults (probably a smaller …

Fifty‐two week follow‐up safety and effectiveness results of dupilumab treatment of moderate‐to‐severe atopic dermatitis from a retrospective, multicentric series

R Ruiz‐Villaverde, J Dominguez‐Cruz… - Dermatologic …, 2019 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, systemic disease that has a multifactorial etiology, where
immune system disorders and epidermal barrier dysfunction are added to the influence of …

Dupilumab shows long-term effectiveness in a large cohort of treatment-refractory atopic dermatitis patients in daily practice: 52-Week results from the Dutch BioDay …

LFM Ariëns, J van der Schaft, LS Spekhorst… - Journal of the American …, 2021 - Elsevier
Background Real-life data on long-term effectiveness and safety of dupilumab in atopic
dermatitis patients are limited. Objective To study 52-week effectiveness and safety of …