Triple-negative breast cancers: systematic review of the literature on molecular and clinical features with a focus on treatment with innovative drugs

A Diana, E Franzese, S Centonze, F Carlino… - Current oncology …, 2018 - Springer
Abstract Purpose of Review Triple-negative breast cancer (TNBC) accounts for 15–20% of
diagnosed breast tumours, with higher incidence in young and African-American women …

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

G Bianchini, JM Balko, IA Mayer, ME Sanders… - Nature reviews Clinical …, 2016 - nature.com
Chemotherapy is the primary established systemic treatment for patients with triple-negative
breast cancer (TNBC) in both the early and advanced-stages of the disease. The lack of …

Dissecting the heterogeneity of triple-negative breast cancer

O Metzger-Filho, A Tutt, E De Azambuja… - Journal of clinical …, 2012 - ascopubs.org
Triple-negative breast cancer (TNBC) accounts for 15% to 20% of breast cancers. It is a
heterogeneous disease, not only on the molecular level, but also on the pathologic and …

Triple-negative breast cancer: molecular subtypes and new targets for therapy

BD Lehmann, JA Pietenpol, AR Tan - American Society of Clinical …, 2015 - ascopubs.org
Triple-negative breast cancer (TNBC) is a molecularly diverse disease. This heterogeneity
has limited the success of targeted therapy in unselected patients to date. Recent …

Update on the treatment of early-stage triple-negative breast cancer

P Sharma - Current treatment options in oncology, 2018 - Springer
Opinion statement Triple-negative breast cancer (TNBC) accounts for 15% of all breast
cancers and is associated with poor long-term outcomes compared to other breast cancer …

Triple negative breast cancer: new therapeutic approaches and BRCA status

G Guney Eskiler, G Cecener, U Egeli, B Tunca - Apmis, 2018 - Wiley Online Library
Treatment of triple negative breast cancer (TNBC) is a clinically challenging problem due to
intriguing clinical and pathologic features of TNBC and natural or induced resistance to …

New strategies for triple-negative breast cancer—deciphering the heterogeneity

IA Mayer, VG Abramson, BD Lehmann… - Clinical cancer …, 2014 - AACR
Triple-negative breast cancer (TNBC) is a heterogeneous disease; gene expression
analyses recently identified six distinct TNBC subtypes, each displaying a unique biology …

Current treatment options in triple negative breast cancer

E Rodler, L Korde, J Gralow - Breast disease, 2011 - content.iospress.com
Triple negative breast cancer (TNBC) refers to a subgroup of breast carcinomas that do not
express the estrogen receptor, progesterone receptor, or human epidermal growth factor …

Therapies for triple negative breast cancer

E Andreopoulou, SJ Schweber… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Triple negative breast cancer (TNBC) is a heterogeneous disease associated
with a high risk of recurrence, and therapeutic options are currently limited to cytotoxic …

Triple-negative breast cancer: new perspectives for novel therapies

YA Mahamodhossen, W Liu, Z Rong-Rong - Medical oncology, 2013 - Springer
Triple-negative breast cancer (TNBC) represents 10–20% of all mammary tumors. It is often
found in younger women and has been associated with poor prognosis, due to aggressive …