The circadian timing system coordinates many aspects of mammalian physiology and
behavior in synchrony with the external light/dark cycle. These rhythms are driven by …

The circadian timekeeper of the mammalian brain resides in the suprachiasmatic nucleus of
the hypothalamus (SCN), and is characterized by rhythmic expression of a set of clock …

Glycogen synthase kinase-3α (GSK-3α) and GSK-3β are intracellular kinases with largely
redundant functions. However, the deletion of each GSK-3 isoform in the mouse has distinct …

Mammalian circadian clocks provide a temporal framework to synchronize biological
functions. To obtain robust rhythms with a periodicity of about a day, these clocks use …

Circadian regulation of gene expression plays a major role in health and disease. The
precise role of the circadian system remains to be clarified, but it is known that circadian …

Circadian clock coordinates behavior and physiology in mammals in response to light and
feeding cycles. Disruption of normal clock function is associated with increased risk for …

The circadian master clock of the mammalian brain resides in the suprachiasmatic nucleus
(SCN) of the hypothalamus. At the molecular level, the clock of the SCN is driven by a …

Circadian locomotor output cycles kaput (CLOCK) is a transcription factor that activates
transcription of clock-controlled genes by heterodimerizing with BMAL1 and binding to E …

The circadian clock mechanism in animals involves an autoregulatory transcriptional
feedback loop in which CLOCK and BMAL1 activate the transcription of the Period and …

Two decades of research identified more than a dozen clock genes and defined a
biochemical feedback mechanism of circadian oscillator function. To identify additional clock …