Exploitation of the folate receptor in the management of cancer and inflammatory disease
CP Leamon, AL Jackman - Vitamins & Hormones, 2008 - Elsevier
Over the last 25+ years, the folate receptor (FR) has emerged as an attractive tumor
biomarker with the potential to be exploited for therapeutic purposes. Increasing evidence …
biomarker with the potential to be exploited for therapeutic purposes. Increasing evidence …
Folate-targeted drug strategies for the treatment of cancer.
CP Leamon - Current opinion in investigational drugs (London …, 2008 - europepmc.org
Increasing evidence suggests that the folate receptor (FR) can be exploited for therapeutic
applications. This endocytosing protein is well known to functionally mediate the cellular …
applications. This endocytosing protein is well known to functionally mediate the cellular …
The folate receptor as a rational therapeutic target for personalized cancer treatment
Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
The folate receptor: what does it promise in tissue-targeted therapeutics?
MDA Salazar, M Ratnam - Cancer and Metastasis Reviews, 2007 - Springer
For over a decade the folate receptor has been intensively investigated as a means for
tumor-specific delivery of a broad range of experimental therapies including several …
tumor-specific delivery of a broad range of experimental therapies including several …
Targeting the folate receptor: improving efficacy in inorganic medicinal chemistry
PM Carron, A Crowley, D O'Shea… - Current Medicinal …, 2018 - ingentaconnect.com
The discovery of the high-affinity, high-specificity folate receptor in mamalian kidney cells,
coupled with the ability of folate to enter cells by folate receptor-mediated endocytosis and …
coupled with the ability of folate to enter cells by folate receptor-mediated endocytosis and …
Folate-targeted chemotherapy
The folate receptor (FR) is a confirmed tumor-associated antigen that binds folate and folate–
drug conjugates with very high affinity and shuttles these bound molecules inside cells via …
drug conjugates with very high affinity and shuttles these bound molecules inside cells via …
[HTML][HTML] Folate receptor as a biomarker and therapeutic target in solid tumors
O Young, N Ngo, L Lin, L Stanbery, JF Creeden… - Current Problems in …, 2023 - Elsevier
Folate is a B vitamin necessary for basic biological functions, including rapid cell turnover
occurring in cancer cell proliferation. Though the role of folate as a causative versus …
occurring in cancer cell proliferation. Though the role of folate as a causative versus …
[HTML][HTML] Assessment of folate receptor-β expression in human neoplastic tissues
J Shen, KS Putt, DW Visscher, L Murphy, C Cohen… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Over-expression of folate receptor alpha on cancer cells has been frequently exploited for
delivery of folate-targeted imaging and therapeutic agents to tumors. Because limited …
delivery of folate-targeted imaging and therapeutic agents to tumors. Because limited …
Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential
The vitamin, folic acid, has become a useful ligand for targeted cancer therapies because it
binds to a tumor-associated antigen known as the folate receptor (FR). By linking folic acid to …
binds to a tumor-associated antigen known as the folate receptor (FR). By linking folic acid to …
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety
of cancers. The current development of folate-targeted cancer therapies has created the …
of cancers. The current development of folate-targeted cancer therapies has created the …