Over the last 25+ years, the folate receptor (FR) has emerged as an attractive tumor
biomarker with the potential to be exploited for therapeutic purposes. Increasing evidence …

Increasing evidence suggests that the folate receptor (FR) can be exploited for therapeutic
applications. This endocytosing protein is well known to functionally mediate the cellular …

Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …

For over a decade the folate receptor has been intensively investigated as a means for
tumor-specific delivery of a broad range of experimental therapies including several …

The discovery of the high-affinity, high-specificity folate receptor in mamalian kidney cells,
coupled with the ability of folate to enter cells by folate receptor-mediated endocytosis and …

The folate receptor (FR) is a confirmed tumor-associated antigen that binds folate and folate–
drug conjugates with very high affinity and shuttles these bound molecules inside cells via …

Folate is a B vitamin necessary for basic biological functions, including rapid cell turnover
occurring in cancer cell proliferation. Though the role of folate as a causative versus …

Over-expression of folate receptor alpha on cancer cells has been frequently exploited for
delivery of folate-targeted imaging and therapeutic agents to tumors. Because limited …

The vitamin, folic acid, has become a useful ligand for targeted cancer therapies because it
binds to a tumor-associated antigen known as the folate receptor (FR). By linking folic acid to …

The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety
of cancers. The current development of folate-targeted cancer therapies has created the …