Liver tumor‐initiating cells (T‐ICs) are capable of self‐renewal and tumor initiation and are
more chemoresistant to chemotherapeutic drugs. The current therapeutic strategies for …

Abstract Background Lup-20 (29)-en-3H-ol (Lupeol), a dietary triterpene, has been shown to
possess multiple pharmacological activities including anti-tumor effects Methods In the …

Tumor-initiating cells (TICs) play a central role in tumor development, metastasis, and
recurrence. In the present study, we investigated the effect of disulfiram (DSF), an inhibitor of …

Background and Aims Liver cancer stem cells (CSCs) exist in the tumor environment and
are critically involved in the initiation and progression of hepatocellular carcinoma (HCC) …

For many malignancies, radiation therapy remains the second option only to surgery in
terms of its curative potential. However, radiation‐induced tumor cell death is limited by a …

Background: Constitutive activation of signal transducer and activator of transcription
signalling 3 (STAT3) has been linked with survival, proliferation and angiogenesis in a wide …

Tumor-initiating cell (TIC) is a subpopulation of cells in tumors that are responsible for tumor
initiation and progression. Recent studies indicate that hepatocellular carcinoma-initiating …

Phosphatase and tensin homolog (P TEN) gene is considered a tumor suppressor gene.
However, PTEN mutations rarely occur in hepatocellular carcinoma (HCC), whereas …

Lupeol, a dietary triterpene, present in many fruits and medicinal plants, has been reported
to possess many pharmacological properties including anti-cancer activities both in vitro and …

Background: Liver cancer stem cells (LCSCs) are responsible for the initiation, progression
and chemoresistance of liver cancer. However, no agent targeting LCSC is available in the …