[HTML][HTML] The 35th anniversary of the discovery of EPR effect: a new wave of nanomedicines for tumor-targeted drug delivery—personal remarks and future prospects
H Maeda - Journal of personalized medicine, 2021 - mdpi.com
This Special Issue on the enhanced permeability and retention (EPR) effect commemorates
the 35th anniversary of its discovery, the original 1986 Matsumura and Maeda finding being …
the 35th anniversary of its discovery, the original 1986 Matsumura and Maeda finding being …
The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
J Fang, H Nakamura, H Maeda - Advanced drug delivery reviews, 2011 - Elsevier
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors related to their anatomical and pathophysiological differences from normal tissues …
tumors related to their anatomical and pathophysiological differences from normal tissues …
Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity
H Maeda - Advanced drug delivery reviews, 2015 - Elsevier
The enhanced permeability and retention (EPR) effect of solid tumors as seen with
nanomedicines and macromolecular drugs is well known. However, many researchers …
nanomedicines and macromolecular drugs is well known. However, many researchers …
Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers
J Fang, W Islam, H Maeda - Advanced drug delivery reviews, 2020 - Elsevier
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …
tumors that is related to their particular anatomical and pathophysiological characteristics …
Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting
H Maeda - Proceedings of the Japan Academy, Series B, 2012 - jstage.jst.go.jp
Tumor and inflammation have many common features. One hallmark of both is enhanced
vascular permeability, which is mediated by various factors including bradykinin, nitric oxide …
vascular permeability, which is mediated by various factors including bradykinin, nitric oxide …
Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls
H Nakamura, F Jun, H Maeda - Expert opinion on drug delivery, 2015 - Taylor & Francis
Introduction: A major problem with conventional antitumor therapeutics is nonselective
delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor …
delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor …
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives
Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …
Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines
K Greish - Journal of drug targeting, 2007 - Taylor & Francis
Over the past two decades cancer has ascended the causes of human death to be number
one or two in many nations world wide. A major limitation inherent to most conventional …
one or two in many nations world wide. A major limitation inherent to most conventional …
[HTML][HTML] The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy
Following its discovery more than 30 years ago, the enhanced permeability and retention
(EPR) effect has become the guiding principle for cancer nanomedicine development. Over …
(EPR) effect has become the guiding principle for cancer nanomedicine development. Over …
Factors affecting the dynamics and heterogeneity of the EPR effect: Pathophysiological and pathoanatomic features, drug formulations and physicochemical factors
R Islam, H Maeda, J Fang - Expert opinion on drug delivery, 2022 - Taylor & Francis
Introduction The enhanced permeability and retention (EPR) effect serves as the foundation
of anticancer nanomedicine design. EPR effect-based drug delivery is an effective strategy …
of anticancer nanomedicine design. EPR effect-based drug delivery is an effective strategy …
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