[HTML][HTML] Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD

MS Muyyarikkandy, M McLeod, M Maguire… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Mitochondrial adaptation during non-alcoholic fatty liver disease (NAFLD) include
remodeling of ketogenic flux and sustained tricarboxylic acid (TCA) cycle activity, which are …

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

PK Luukkonen, S Dufour, K Lyu… - Proceedings of the …, 2020 - National Acad Sciences
Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic
fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite …

Investigating the link between ketogenic diet, NAFLD, mitochondria, and oxidative stress: a narrative review

A Paoli, G Cerullo - Antioxidants, 2023 - mdpi.com
Together with the global rise in obesity and metabolic syndrome, the prevalence of
individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically …

Dietary macronutrient composition differentially modulates the remodeling of mitochondrial oxidative metabolism during NAFLD

N Kattapuram, C Zhang, MS Muyyarikkandy… - Metabolites, 2021 - mdpi.com
Diets rich in fats and carbohydrates aggravate non-alcoholic fatty liver disease (NAFLD), of
which mitochondrial dysfunction is a central feature. It is not clear whether a high …

Mitochondrial adaptation in nonalcoholic fatty liver disease: novel mechanisms and treatment strategies

NE Sunny, F Bril, K Cusi - Trends in Endocrinology & Metabolism, 2017 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is prevalent in patients with obesity or type 2
diabetes. Nonalcoholic steatohepatitis (NASH), encompassing steatosis with inflammation …

Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease

NE Sunny, S Kalavalapalli, F Bril… - American Journal …, 2015 - journals.physiology.org
Elevated plasma branched-chain amino acids (BCAA) in the setting of insulin resistance
have been relevant in predicting type 2 diabetes mellitus (T2DM) onset, but their role in the …

A bioenergetics systems evaluation of ketogenic diet liver effects

LJ Hutfles, HM Wilkins, SJ Koppel… - Applied Physiology …, 2017 - cdnsciencepub.com
Ketogenic diets induce hepatocyte fatty acid oxidation and ketone body production. To
further evaluate how ketogenic diets affect hepatocyte bioenergetic infrastructure, we …

The ketogenic diet prevents steatosis and insulin resistance by reducing lipogenesis, diacylglycerol accumulation and protein kinase C activity in male rat liver

S Jani, D Da Eira, M Stefanovic… - The Journal of …, 2022 - Wiley Online Library
Obesity‐associated insulin resistance plays a major role in the pathogenesis of non‐
alcoholic fatty liver disease (NAFLD). The accumulation of diacylglycerol (DAG), ceramides …

[HTML][HTML] Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome

DA d'Avignon, P Puchalska, B Ercal, YJ Chang… - JCI insight, 2018 - ncbi.nlm.nih.gov
While several molecular targets are under consideration, mechanistic underpinnings of the
transition from uncomplicated nonalcoholic fatty liver disease (NAFLD) to nonalcoholic …

[HTML][HTML] A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice

F Long, MR Bhatti, A Kellenberger, W Sun… - Molecular …, 2023 - Elsevier
Objectives Metabolic-associated fatty liver disease (MAFLD) is the most common chronic
liver disease that can range from hepatic steatosis to non-alcoholic steatohepatitis (NASH) …