Background Development of insulin resistance (IR) may be important in the pathogenesis of
both metabolic syndrome and type 2 diabetes mellitus. Few data are available regarding the …

OBJECTIVE: Development of insulin resistance (IR) and the progressive failure of the
pancreatic beta-cell function (BCF) may be important in the pathogenesis of type 2 diabetes …

Background—Recent studies have shown that type 2 diabetes is preventable by both
lifestyle interventions and medications that influence primary glucose metabolism. Whether …

Aims To assess the effect of fibric acid derivative bezafibrate on incidence of type 2 diabetes
in obese patients over a median 6.3 years follow-up period. Methods and results The study …

Background A consistent relationship between metabolic syndrome (MS) and myocardial
infarction (MI) has been demonstrated. We evaluated the effect of bezafibrate retard, a fibric …

PURPOSE: To determine whether hypertriglyceridemia is associated with systemic
inflammation, which may contribute to the increased cardiovascular risk in patients who …

Context: Fenofibrate is a peroxisome proliferator-activated receptor α agonist widely used in
clinical practice, but its mechanism of action is incompletely understood. Objective: The aim …

Background The hypoglycemic effect of bezafibrate is well established, but administration to
a large population of patients with diabetes has not been reported. We investigated glycemic …

OBJECTIVE The purpose of this study was to test the hypothesis that bezafibrate, an
approved fibrate, can prevent or delay type 2 diabetes. RESEARCH DESIGN AND …

Background Epidemiologic studies have suggested that hypertriglyceridemia and insulin
resistance are related to the development of colon cancer. Nuclear peroxisome proliferator …