The human antibody response to influenza virus infection plays a protective role against re-
infection, yet little molecular detail is available regarding how human antibodies, when …

Highlights•Broadly neutralizing antibodies against influenza A and B represents a safe and
affordable alternative to convalescent plasma.•The large majority of broadly neutralizing …

Current influenza virus vaccines rely upon the accurate prediction of circulating virus strains
months in advance of the actual influenza season in order to allow time for vaccine …

Introduction: Antibodies directed against influenza virus execute their protective function by
exploiting a variety of effector mechanisms. Neutralizing antibodies have been thoroughly …

Despite available antivirals and vaccines, influenza continues to be a major cause of
mortality worldwide. Vaccination generally induces an effective, but strain-specific antibody …

Human monoclonal antibodies have been identified which neutralize broad spectra of
influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies …

Vaccines are the gold standard for the control and prevention of infectious diseases, but a
number of important human diseases remain challenging targets for vaccine development …

Highlights•A vaccine that induces broadly-neutralizing antibodies would not need annual
updates.•Neutralizing epitopes are almost always conformational and discontinuous, not …

The antigenic diversity of human influenza viruses represents a challenge to the
development of vaccines with durable immune protection. In addition, small molecule anti …

The natural human antibody response is a rich source of highly specific, neutralizing and
self-tolerant therapeutic reagents. Recent advances have been made in isolating and …