Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

WE Lyons, LA Mamounas… - Proceedings of the …, 1999 - National Acad Sciences
Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons
in the central nervous system. However, the role of endogenous BDNF in the development …

[HTML][HTML] Peripheral brain-derived neurotrophic factor and contactin-1 levels in patients with attention-deficit/hyperactivity disorder

LJ Wang, CC Wu, MJ Lee, MC Chou, SY Lee… - Journal of clinical …, 2019 - mdpi.com
Brain-derived neurotrophic factor (BDNF) facilitates neuronal growth and plasticity, and is
crucial for learning and memory. Contactin-1 (CNTN1) is a member of the subfamily of …

Translational findings on brain-derived neurotrophic factor and anxiety: contributions from basic research to clinical practice

AC Domingos da Silveira da Luz, G Pereira Dias… - …, 2013 - karger.com
Abstract Background/Aims: Anxious responses are evolutionarily adaptive, but excessive
fear can become disabling and lead to anxiety disorders. Translational models of anxiety …

[HTML][HTML] Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters

H You, B Lu - Biomolecules, 2023 - mdpi.com
The gene encoding brain-derived neurotrophic factor (Bdnf) consists of nine non-coding
exons driven by unique promoters, leading to the expression of nine Bdnf transcripts that …

[HTML][HTML] Genetic and epigenetic regulation of the brain-derived neurotrophic factor in the central nervous system

GA Martínez-Levy, CS Cruz-Fuentes - The Yale journal of biology …, 2014 - ncbi.nlm.nih.gov
The BDNF is required for the development and proper function of the central nervous
system, where it is involved in a variety of neural and molecular events relevant to cognition …

Brain‐derived neurotrophic factor predominantly regulates the expression of synapse‐related genes in the striatum: Insights from in vitro transcriptomics

H Koshimizu, H Matsuoka, Y Nakajima… - …, 2021 - Wiley Online Library
Aim The striatum, a main component of the basal ganglia, is a critical part of the motor and
reward systems of the brain. It consists of GABAergic and cholinergic neurons and receives …

Is autism caused by early hyperactivity of brain-derived neurotrophic factor?

SJ Tsai - Medical hypotheses, 2005 - Elsevier
Autism, a childhood-onset neurodevelopmental disorder, is characterized by disturbances in
socialization and language skills, as well as in perception. Several studies indicate the …

Is altered BDNF biosynthesis a general feature in patients with cognitive dysfunctions?

D Carlino, M De Vanna, E Tongiorgi - The Neuroscientist, 2013 - journals.sagepub.com
Severe cognitive deficits are a frequent outcome of both neurodegenerative and
neurodevelopmental disorders. In the attempt to define new clinical biomarkers, current …

Brain‐derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions

K Hashimoto - Psychiatry and clinical neurosciences, 2010 - Wiley Online Library
Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), are
the most prevalent psychiatric conditions, and are also among the most severe and …

Toward a pathophysiology of attention-deficit/hyperactivint disorder

FX Castellanos - Clinical Pediatrics, 1997 - journals.sagepub.com
Converging insights into attention-deficit/hyperactivity disorder (ADHD) support the notion
that ADHD is best characterized behaviorally as a disorder of self-regulation or executive …