It has recently been proposed that experimental autoimmune encephalomyelitis, once
considered the classical Th1 disease, is predominantly Th17 driven. In this study we show …

Background There is consensus that experimental autoimmune encephalomyelitis (EAE)
can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the …

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune demyelinating diseases of the central nervous system (CNS) …

Multiple sclerosis (MS) is the most important autoimmune disease of the central nervous
system (CNS). Its animal model experimental autoimmune encephalomyelitis (EAE) has …

IL-17–producing CD8+ T (Tc17) cells are detectible in multiple sclerosis (MS) lesions;
however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we …

During the development of experimental autoimmune encephalomyelitis (EAE), the
proportion of pathogenic and myelin-specific cells within CNS-infiltrating cytokine-producing …

It has been firmly established that IL-23 polarized TH17 cells are potent effectors in the
pathogenesis of experimental autoimmune encephalitomyelitis (EAE). However, the relative …

Both T cells and B cells are implicated in the pathology of multiple sclerosis (MS), but how
these cells cooperate to drive disease remains unclear. Recent studies using experimental …

Experimental autoimmune encephalomyelitis (EAE) is a model of human multiple sclerosis
induced by autoreactive Th cells that mediate tissue inflammation and demyelination in the …

The discovery of the T helper (Th) 17 lineage, involved in the protection against fungal and
extracellular bacterial infections, has profoundly revolutionized our current understanding of …