A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …

Macrophages are the primary targets of Mycobacterium tuberculosis infection; the early
events of macrophage interaction with M. tuberculosis define subsequent progression and …

The immune system is inordinately complex with many interacting components determining
overall outcomes. Mathematical and computational modelling provides a useful way in …

The classical model of immunity posits that the immune system reacts to pathogens and
injury and restores homeostasis. Indeed, a century of research has uncovered the means …

Systems biology is an emerging discipline that combines high-content, multiplexed
measurements with informatic and computational modeling methods to better understand …

Inflammation is a rapid yet coordinated response that can lead to the destruction of microbes
and host tissue. Triggers capable of inducing an inflammatory response include tissue …

In the face of ineffective vaccines, increasing antibiotic resistance and the decline in new
antibacterial drugs in the pipeline, tuberculosis (TB) still remains pandemic. Exposure to …

Highlights•TB is a nonresolving inflammatory disease.•Inflammatory mediators are
intertwined in networks during TB.•The pattern of infected cell death affects inflammation in …

Inflammation is a normal, robust physiological process. It can also be viewed as a complex
system that senses and attempts to resolve homeostatic perturbations initiated from within …

The immune system provides organisms with robustness against pathogen threats, yet it
also often adversely affects the organism as in autoimmune diseases. Recently, the …