Infections caused by cytomegalovirus (CMV) resistantin vitroto ganciclovir, defined as
requiring> 6 µmol of ganciclovir for ED50 have developed in some AIDS patients with …

Oral valganciclovir is a new and highly efficacious alternative to the chronic administration of
ganciclovir in the treatment of cytomegalovirus (CMV) retinitis in HIV-infected patients. In …

Objective: To document response to foscarnet salvage therapy in patients with
cytomegalovirus (CMV) retinitis who are intolerant of or resistant to ganciclovir. Methods …

To determine whether therapeutic intravitreal concentrations of ganciclovirare achieved after
intravenous administration, vitreous samples were obtained intraoperatively from 23 eyes of …

A method for ganciclovir determination in human serum and plasma has been developed
and validated. The method has a lower limit of quantification (LLOQ) adequate for sensitive …

Background. In the mid-1990s, the incidence of cytomegalovirus (CMV) resistance to
ganciclovir was estimated to be∼ 25% by 1 year after diagnosis of retinitis in patients with …

Background: Cytomegalovirus (CMV) retinitis is the most common opportunistic ocular
infection in AIDS patients, and frequently leads to blindness if untreated. Intravitreal …

Cidofovir is an antiviral nucleotide analogue with significant activity against cytomegalovirus
(CMV) and other herpesviruses. The drug is indicated for the treatment of CMV retinitis, a …

Objectives: To study the temporal relationships between cytomegalovirus (CMV) viral load
and specific UL97 mutations in polymorphonuclear leukocytes (PMNL) and plasma samples …

Induction regimens of foscarnet and ganciclovir are highly effective in arresting
cytomegalovirus (CMV) retinitis in patients with AIDS. Chronic maintenance therapy is …