Previous investigations have raised the possibility that the digoxin-quinidine interaction is
associated with a reduction in the positive inotropic effect of digoxin due to displacement of …

Digoxin concentrations in serum, myocardium, 3 separate skeletal muscles, kidney, liver,
and 5 sites in the brain were measured in 26 dogs given 12-alpha 3 H-digoxin. Ten of the …

Systolic time intervals (QS 2-I and LVET-I) and echocardiographically determined ejection
fraction and velocity of circumferential fiber shortening were recorded in 10 healthy …

To investigate the basis for a clinically important digitalis-quinidine interaction that is
characterized by increases in serums digoxin concentrations when quinidine is …

Quinidine elevates serum digoxin concentration in part by reducing the volume of
distribution of digoxin, which implies that quinidine displaces digoxin from tissues. The …

The effects of the digoxin‐quinidine interaction on cardiac function was examined in healthy
subjects. Our results indicate that while serum digoxin levels were elevated, the improved …

The time course of the rise in serum digoxin concentration was followed in 18 patients
treated with digoxin as quinidine treatment was started with a loading dose. The mean …

Administration of quinidine with digoxin increased serum digoxin concentrations in 79
patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the …

Tissue concentrations of tritiated digoxin in the dog are altered by simultaneous
administration of quinidine. Serum levels rise as tissue concentration decreases significantly …

It is now well established that administration of the cardiac anti-arrhythmic drug, quinidine,
can produce significantly elevated plasma levels of simultaneously administered digoxin in …