Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer
E Gillespie, SE Leeman, LA Watts… - Proceedings of the …, 2011 - National Acad Sciences
Patients with chronic ulcerative colitis (UC) are at high risk for developing colorectal cancer.
In this study, archival formalin-fixed paraffin-embedded colonic tissue from patients with UC …
In this study, archival formalin-fixed paraffin-embedded colonic tissue from patients with UC …
Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer
B Pagán, AA Isidro, D Coppola, Z Chen… - Anticancer …, 2010 - ar.iiarjournals.org
Aim: The role of substance P and the neurokinin-1 receptor (NK-1R) in the transition from
inflammation to dysplasia in inflammatory bowel disease is not clear. Materials and …
inflammation to dysplasia in inflammatory bowel disease is not clear. Materials and …
Neurokinin‐1 receptor (NK‐1R) expression is induced in human colonic epithelial cells by proinflammatory cytokines and mediates proliferation in response to …
T Goode, T O'Connor, A Hopkins… - Journal of cellular …, 2003 - Wiley Online Library
We have previously shown that the receptor for substance P (SP), neurokinin‐1 receptor (NK‐
1R), is a marker of human mucosal but not peripheral mononuclear cells. In the present …
1R), is a marker of human mucosal but not peripheral mononuclear cells. In the present …
Substance P (neurokinin-1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine
D Renzi, B Pellegrini, F Tonelli, C Surrenti… - The American journal of …, 2000 - Elsevier
Increasing evidence suggests that tachykinins are involved in the control of
pathophysiological states, such as inflammation. The precise localization of tachykinin …
pathophysiological states, such as inflammation. The precise localization of tachykinin …
Neurokinin-1 receptor expression in inflammatory bowel disease: molecular quantitation and localisation
T Goode, J O'Connell, P Anton, H Wong, J Reeve… - Gut, 2000 - gut.bmj.com
BACKGROUND Substantial evidence implicates the neuropeptide substance P (SP) in
mucosal immunoinflammatory responses. Autoradiographic studies have suggested a …
mucosal immunoinflammatory responses. Autoradiographic studies have suggested a …
[HTML][HTML] Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer
H Friess, Z Zhu, V Liard, X Shi, SV Shrikhande… - Laboratory …, 2003 - nature.com
Abstract The neurokinin-1 receptor (NK-1R) and its ligand substance P (SP) are involved in
the pathogenesis of certain neural tumors. Because nerves are significantly altered in …
the pathogenesis of certain neural tumors. Because nerves are significantly altered in …
[HTML][HTML] Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia
RA Isidro, ML Cruz, AA Isidro, A Baez… - World Journal of …, 2015 - ncbi.nlm.nih.gov
AIM: To determine the expression of neurokinin-1 receptor (NK-1R), phosphorylated
epidermal growth factor receptor (pEGFR), cyclooxygenase-2 (Cox-2), and vitamin D …
epidermal growth factor receptor (pEGFR), cyclooxygenase-2 (Cox-2), and vitamin D …
Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis
E Burcher, F Shang, FJ Warner, Q Du… - … of Pharmacology and …, 2008 - ASPET
Neurokinin A (NKA) is an important spasmogen in human colon. We examined inflammatory
disease-related changes in the tachykinin NK2 receptor system in human sigmoid colon …
disease-related changes in the tachykinin NK2 receptor system in human sigmoid colon …
Differential expression of neurokinin-1 receptor by human mucosal and peripheral lymphoid cells
T Goode, J O'Connell, WZ Ho… - Clinical Diagnostic …, 2000 - Am Soc Microbiol
Substance P (SP) has been implicated in peripheral and mucosal neuroimmunoregulation.
However, confusion remains regarding immunocyte expression of the receptor for SP …
However, confusion remains regarding immunocyte expression of the receptor for SP …
[HTML][HTML] Neurokinin-1 receptor: a new promising target in the treatment of cancer
M Munoz, R Covenas - Discovery medicine, 2010 - discoverymedicine.com
Substance P (SP) has a widespread distribution in the whole body. After binding to the
neurokinin-1 (NK-1) receptor, SP regulates biological functions related to cancer: tumor cell …
neurokinin-1 (NK-1) receptor, SP regulates biological functions related to cancer: tumor cell …
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