Patients with chronic ulcerative colitis (UC) are at high risk for developing colorectal cancer.
In this study, archival formalin-fixed paraffin-embedded colonic tissue from patients with UC …

Aim: The role of substance P and the neurokinin-1 receptor (NK-1R) in the transition from
inflammation to dysplasia in inflammatory bowel disease is not clear. Materials and …

We have previously shown that the receptor for substance P (SP), neurokinin‐1 receptor (NK‐
1R), is a marker of human mucosal but not peripheral mononuclear cells. In the present …

Increasing evidence suggests that tachykinins are involved in the control of
pathophysiological states, such as inflammation. The precise localization of tachykinin …

BACKGROUND Substantial evidence implicates the neuropeptide substance P (SP) in
mucosal immunoinflammatory responses. Autoradiographic studies have suggested a …

Abstract The neurokinin-1 receptor (NK-1R) and its ligand substance P (SP) are involved in
the pathogenesis of certain neural tumors. Because nerves are significantly altered in …

AIM: To determine the expression of neurokinin-1 receptor (NK-1R), phosphorylated
epidermal growth factor receptor (pEGFR), cyclooxygenase-2 (Cox-2), and vitamin D …

Neurokinin A (NKA) is an important spasmogen in human colon. We examined inflammatory
disease-related changes in the tachykinin NK2 receptor system in human sigmoid colon …

Substance P (SP) has been implicated in peripheral and mucosal neuroimmunoregulation.
However, confusion remains regarding immunocyte expression of the receptor for SP …

Substance P (SP) has a widespread distribution in the whole body. After binding to the
neurokinin-1 (NK-1) receptor, SP regulates biological functions related to cancer: tumor cell …