Abstract Targeting Glutathione peroxidase 4 (GPX4) has become a promising strategy for
drug-resistant cancer therapy via ferroptosis induction. It was found that the GPX4 inhibitors …

Ferroptosis, characterized by excessive iron accumulation and lipid peroxidation, is a novel
form of iron-dependent cell death, which is morphologically, genetically, and biochemically …

Abstract Glutathione peroxidase 4 (GPX4) is the most promising target for inducing
ferroptosis. GPX4-targeting strategies primarily focus on inhibiting its activity or adjusting its …

Ferroptosis is an iron-dependent cell death caused by the accumulation of lipid
peroxidation. The glutathione peroxidase 4 (GPX4) is an antioxidative enzyme and a major …

Ferroptosis is an iron-dependent, non-apoptotic form of cell death involving in various
disease processes. Mechanistically, glutathione peroxidase 4 (GPX4) which belongs to the …

Background TNBC is the most aggressive breast cancer with higher recurrence and
mortality rate than other types of breast cancer. There is an urgent need for identification of …

Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the
key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer …

Background Cancer is one of the major threats to human health and current cancer
therapies have been unsuccessful in eradicating it. Ferroptosis is characterized by iron …

Glutathione peroxidase 4 (GPX4) is an intracellular enzyme that oxidizes glutathione while
reducing lipid peroxides and is a promising target for cancer therapy. To date, several GPX4 …

Targeted degradation of proteins, especially those regarded as undruggable or difficult to
drug, attracts wide attention to develop novel therapeutic strategies. Glutathione peroxidase …