GSNFS: Gene subnetwork biomarker identification of lung cancer expression data

N Doungpan, W Engchuan, JH Chan… - BMC medical genomics, 2016 - Springer
Background Gene expression has been used to identify disease gene biomarkers, but there
are ongoing challenges. Single gene or gene-set biomarkers are inadequate to provide …

DM-MOGA: a multi-objective optimization genetic algorithm for identifying disease modules of non-small cell lung cancer

J Shang, X Zhu, Y Sun, F Li, X Kong, JX Liu - BMC bioinformatics, 2023 - Springer
Background Constructing molecular interaction networks from microarray data and then
identifying disease module biomarkers can provide insight into the underlying pathogenic …

Computational inference of gene co-expression networks for the identification of lung carcinoma biomarkers: an ensemble approach

FM Delgado-Chaves, F Gómez-Vela, M García-Torres… - Genes, 2019 - mdpi.com
Gene Networks (GN), have emerged as an useful tool in recent years for the analysis of
different diseases in the field of biomedicine. In particular, GNs have been widely applied for …

Predicting Diagnostic Gene Biomarkers for Non‐Small‐Cell Lung Cancer

B Liang, Y Shao, F Long… - BioMed Research …, 2016 - Wiley Online Library
Lung cancer is the primary reason for death due to cancer worldwide, and non‐small‐cell
lung cancer (NSCLC) is the most common subtype of lung cancer. Most patients die from …

A network-based biomarker approach for molecular investigation and diagnosis of lung cancer

YC Wang, BS Chen - BMC medical genomics, 2011 - Springer
Background Lung cancer is the leading cause of cancer deaths worldwide. Many studies
have investigated the carcinogenic process and identified the biomarkers for signature …

Non‑small-cell lung cancer pathological subtype‑related gene selection and bioinformatics analysis based on gene expression profiles

J Chen, X Dong, X Lei, Y Xia… - Molecular and …, 2018 - spandidos-publications.com
Lung cancer is one of the most common malignant diseases and a major threat to public
health on a global scale. Non-small-cell lung cancer (NSCLC) has a higher degree of …

De Novo and Supervised Endophenotyping Using Network-Guided Ensemble Learning

SJ Larsen, HHHW Schmidt, J Baumbach - Systems Medicine, 2020 - liebertpub.com
Introduction: Precision medicine requires the accurate identification of genes and pathways
that mechanistically define a disease phenotype. Modern omics may deliver this, but has …

Identifying Tumorigenesis and Prognosis‐Related Genes of Lung Adenocarcinoma: Based on Weighted Gene Coexpression Network Analysis

M Yi, T Li, S Qin, S Yu, Q Chu, A Li… - BioMed research …, 2020 - Wiley Online Library
Lung adenocarcinoma is the most frequently diagnosed subtype of nonsmall cell lung
cancer. The molecular mechanisms of the initiation and progression of lung …

Gene-Network-Based Feature Set (GNFS) for expression-based cancer classification

N Doungpan, W Engchuan, A Meechai… - Journal of Medical …, 2016 - ingentaconnect.com
Identification of cancer biomarker using gene expression data is a challenging task. Many
strategies have been proposed to identify signature genes for distinguishing cancer from …

A pathway-based strategy to identify biomarkers for lung cancer diagnosis and prognosis

M Sheng, X Xie, J Wang, W Gu - Evolutionary Bioinformatics, 2019 - journals.sagepub.com
Current research has identified several potential biomarkers for lung cancer diagnosis or
prognosis. However, most of these biomarkers are derived from a relatively small number of …