Introduction: The 4-factor prothrombin complex concentrates (4F-PCCs) are very effective in
urgent reversal of vitamin K antagonist (VKA) anticoagulant therapy, including correction of …

Background A four-factor prothrombin complex concentrate (4F-PCC) has recently been
approved by the FDA for urgent vitamin K antagonist (VKA, eg warfarin) reversal in patients …

Background Rapid reversal of vitamin K antagonist (VKA)-induced anticoagulation is often
necessary for patients needing urgent surgical or invasive procedures. The optimum means …

Background—Patients experiencing major bleeding while taking vitamin K antagonists
(VKAs) require rapid VKA reversal. We performed a prospective clinical trial to compare non …

Objectives Early reversal of anticoagulation improves outcomes in major bleeding and
emergency surgery. To reverse vitamin K antagonists (VKA), vitamin K in addition to …

Rapid vitamin K antagonist (VKA) reversal is required in patients experiencing major
bleeding or requiring urgent surgery. Four-factor prothrombin complex concentrate (4F-PCC; …

Major bleeding is a serious and potentially fatal complication of treatment with vitamin K
antagonists (VKAs). Prothrombin complex concentrates (PCCs) can substantially shorten the …

Vitamin K antagonists (VKAs) have been used for decades for the treatment and prophylaxis
of thromboembolic events. Due to their wide range of therapeutic indications, they are the …

Study Objectives: Rapid anticoagulant reversal is essential for subjects on vitamin K
antagonists (VKA) that present with acute, major bleeding. The International Normalized …

Objectives Clinicians often need to rapidly reverse vitamin K antagonists (VKA s) in the
setting of major hemorrhage or urgent need for surgery. Little is known about the safety …