BACKGROUND & AIMS: The gut-brain axis, which transmits nutrient information from the
gastrointestinal tract to the brain, is important for the detection of dietary nutrients. We used …

Recent studies have shown the nutrient-sensing systems transmitting nutritive information
from the gut to the brain. However neural activity evoked by ingested dietary nutrients has …

BACKGROUND & AIMS: The hypothalamus and brain stem have important roles in
regulating food intake; the roles of other nonhomeostatic centers in detecting nutrient …

Volume and chemical characteristics of meals in the gut have been proposed to generate
vagal afferent signals that mediate the negative feedback control of ingestion and gastric …

Duodenal infusions of macronutrients inhibit sham and normal feeding. Neural substrates of
this response were studied by infusing glucose, linoleic acid, an amino acid mixture, saline …

l-glutamate, an umami taste substance, is a key molecule coupled to a food intake signaling
pathway. Furthermore, recent studies have unveiled new roles for dietary glutamate on gut …

The ability of intraintestinal nutrient infusions to suppress sham feeding was examined in
intact rats and in rats with total subdiaphragmatic vagal transections. Vagotomy abolished …

We previously showed that hypothalamic neuronal activity, as measured by the blood
oxygen level-dependent (BOLD) functional MRI signal, declines in response to oral glucose …

Normal rats, and rats with lesions in the lateral hypothalamic area (LHA), ventromedial
hypothalamus (VMH), or with subdiaphragmatic vagotomies were duodenally infused with …

During digestion, macronutrients are sensed within the small intestine. This sensory process
is dependent upon the action of gut mediators, such as cholecystokinin (CCK) or serotonin …