Latanoprost, the active principle of XalatanR eye drops, is a prostaglandin F2α analogue in
widespread use for the treatment of glaucoma. During chronic treatment with the drug, an …

The melanocytes in the mammalian eye have been thought to produce melanin only during
fetal development and in the very young individual. The recent discovery that latanoprost, a …

The prostaglandin F2α derivative, latanoprost (LT), used in glaucoma treatment, can induce
pigmentation in irises of patients with hazel or heterochromatic eye colour. The mechanism …

Latanoprost, a phenyl-substituted analogue of prostaglandin F2α administered as eye
drops, in-duces increased melanogenesis in the iridial melanocytes of monkeys. Similar …

Topical use of latanoprost for glaucoma can lead to an increase in iris and eye lash
pigmentation but the precise mechanism is unclear. To study the possible effect of this drug …

Latanoprost, a new ocular hypotensive prostaglandin F2α, analogue prodrug, was found to
induce increased pigmentation of monkey irides in chronic toxicity studies. This prompted us …

The PGF2α derivative, latanoprost, is a recent anti-glaucoma drug that has been reported to
induce a discrete incidence of increased iris pigmentation in men. The present experiments …

Several prostaglandin analogues used for glaucoma treatment cause increased
pigmentation of the iris. The purpose of the present study was investigate whether …

Purpose: Latanoprost, the active principle of XalatanR eye drops, has been shown to cause
increased iridial pigmentation as a side‐effect in some patients. The purpose of the present …

Latanoprost is a prostaglandin analogue with well-established efficacy in the treatment of
open-angle glaucoma and ocular hypertension. Once-daily administration of this drug for up …