Growth hormone deficiency or resistance resulting from spontaneous or experimentally
produced mutations in laboratory mice delay aging and increase lifespan. Alterations in …

Recent evidence suggests that alterations in insulin/insulin–like growth factor 1 (IGF1)
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …

Hormones, like insulin and insulin-like growth factor 1 (IGF-1), are thought to be deeply
involved with longevity. Lower species have been the source for most of our current …

In invertebrates, signaling pathways homologous to mammalian insulin and insulin-like
growth factor (IGF-1) signal transduction have a major role in the control of longevity. There …

Ageing may be controlled by a genetic-hormonal system that may have originated from a
very early common ancestor. One of the pathways that has been implicated in ageing is the …

Although the underlying mechanisms of longevity are not fully understood, it is known that
mutation in genes that share similarities with those in humans involved in the insulin/insulin …

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

Ageing research has been revolutionized by the use of model organisms to discover genetic
alterations that can extend lifespan. In the last 5 years alone, it has become apparent that …

It has been demonstrated in invertebrate species that the evolutionarily conserved insulin
and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of …

An organism's well-being is facilitated by numerous molecular and biochemical pathways
that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the …